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Table 1 Clinical, echocardiographic and cardiac MRI (CMR) findings in the MYBPC group and in the Archive group

From: Cardiovascular magnetic resonance of mitral valve length in hypertrophic cardiomyopathy

 

MYBPC control

MYBPC G+/LVH-

MYBPC G+/LVH+

P

Archive control

Archive HCM

P

Patients, n

20

15

32

 

71

80

 

Age, y

46 ± 17

33 ± 16

50 ± 11

.007*

53 ± 14

55 ± 16

.42

Men, n

5 (25 %)

3 (20 %)

20 (63 %)

<.001*

44 (62 %)

51 (64 %)

.82

BSA, m2

1.87 ± 0.28

1.75 ± 0.18

1.94 ± 0.20

.004*

1.88 ± 0.22

1.90 ± 0.21

.44

Height, cm

169 ± 10

167 ± 6

174 ± 9

.040*

171 ± 10

170 ± 8

.718

Weight, kg

76 ± 24

68 ± 13

81 ± 14

.005*

77 ± 16

80 ± 16

.248

BMI

27 ± 8

24 ± 4

27 ± 4

.129

26 ± 4

28 ± 5

.141

NYHA, n

 I

20 (100 %)

15 (100 %)

28 (88 %)

 

N.A.

N.A.

 

 II

-

-

4 (13 %)

 

N.A.

N.A.

 

LVOT gradient, mmHg

7.1 ± 2.9

5.7 ± 1.8

8.5 ± 11.4

.42

N.A.

N.A.

 

LVMWT, mm

10.2 ± 2.8

9.5 ± 1.6

22.1 ± 5.7

<.001*

10.5 ± 2.5

19.2 ± 4.5

<.001*

LVMI, g/m2

45 ± 9

49 ± 13

68 ± 21

<.001*

N.A.

N.A.

 

LVEDVI, ml/m2

78 ± 13

78 ± 15

74 ± 14

.55

75 ± 17

74 ± 22

.49

LVESVI, ml/m2

32 ± 10

30 ± 7

28 ± 10

.13

33 ± 9

31 ± 15

.019*

LVEF, %

60 ± 8

62 ± 5

63 ± 9

.12

55 ± 7

59 ± 10

.007*

AML, mm (range)

25.0 ± 2.9 (20–30)

24.7 ± 3.8 (19–33)

24.8 ± 4.1 (19–42)

.81

25.1 ± 3.7 (16–36)

25.3 ± 3.9 (17–41)

.66

PML, mm (range)

10.6 ± 1.9 (8–15)

11.1 ± 3.4 (6–16)

12.7 ± 2.8 (9–22)

.056

14.4 ± 3.6 (7–24)

14.2 ± 3.5 (8–25)

.55

AML index, mm/m2

13.7 ± 2.2

14.2 ± 2.2

12.9 ± 2.5

.034*

13.5 ± 2.4

13.8 ± 2.5

.68

PML index, mm/m2

5.8 ± 1.2

6.2 ± 1.5

6.6 ± 1.5

.214

7.8 ± 2.2

7.6 ± 1.9

.90

  1. MYBPC-control healthy controls without MYBPC mutation, MYBPC G+/LVH- MYBPC mutation carriers without LVH, MYBPC G+/LVH+ MYBPC mutation carriers with LVH, Archive control control subjects with normal CMR findings, Archive HCM subjects with HCM in CMR, BSA body surface area, BMI body mass index, NYHA New York Heart Association functional class, LVOT gradient left ventricular outflow tract gradient, LVMWT left ventricular maximal wall thickness, LVMI left ventricular mass index, LVEDVI left ventricular end-diastolic volume index, LVESVI left ventricular end-systolic volume index, LVEF left ventricular ejection fraction, AML anterior mitral leaflet length, PML posterior mitral leaflet length, AML index AML indexed for BSA, PML index PML indexed for BSA, N.A. not available. * Significance P < 0.05