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Table 6 Diagnostic performance of Fermi and DP modeling in per vessel and per patient analysis

From: Quantitative assessment of myocardial blood flow in coronary artery disease by cardiovascular magnetic resonance: comparison of Fermi and distributed parameter modeling against invasive methods

Haemodynamic parameter-Model

Sensitivity

Specificity

PPV

NPV

Fermi-MBF PV

0.85 (0.76 to 0.94)

0.54 (0.43 to 0.65)

0.51 (0.39 to 0.63)

0.86 (0.74 to 0.98)

DP-MBF PV

0.89 (0.79 to 0.99)

0.63 (0.52 to 0.74)

0.58 (0.48 to 0.68)

0.91 (0.84 to 0.98)

Fermi-MPR PV

0.69 (0.50 to 0.88)

0.54 (0.40 to 0.68)

0.46 (0.32 to 0.60)

0.76 (0.62 to 0.90)

DP-MPR PV

0.85 (0.72 to 0.98)

0.61 (0.48 to 0.74)

0.55 (0.43 to 0.67)

0.88 (0.76 to 1.00)

Fermi-MPR2 PV

0.73 (0.58 to 0.88)

0.65 (0.51 to 0.79)

0.54 (0.40 to 0.68)

0.81 (0.68 to 0.94)

DP-MPR2 PV

0.77 (0.62 to 0.92)

0.70 (0.56 to 0.84)

0.58 (0.46 to 0.70)

0.84 (0.75 to 0.94)

Fermi-MBF PP

0.78 (0.66 to 0.90)

0.88 (0.76 to 1.00)

0.93 (0.86 to 1.00)

0.66 (0.55 to 0.77)

DP-MBF PP

0.96 (0.91 to 1.00)

0.92 (0.85 to 0.99)

0.96 (0.91 to 1.00)

0.92 (0.84 to 1.00)

Fermi-MPR PP

0.69 (0.55 to 0.83)

0.83 (0.70 to 0.96)

0.90 (0.80 to 1.00)

0.58 (0.46 to 0.70)

DP-MPR PP

0.88 (0.76 to 1.00)

0.88 (0.78 to 0.98)

0.94 (0.88 to 1.00)

0.78 (0.66 to 0.90)

Fermi-MPR2 PP

0.80 (0.66 to 0.94)

0.79 (0.62 to 0.94)

0.89 (0.78 to 1.00)

0.66 (0.55 to 0.77)

DP-MPR2 PP

0.92 (0.86 to 0.98)

0.83 (0.74 to 0.92)

0.92 (0.86 to 0.98)

0.83 (0.73 to 0.93)

  1. Parentheses show 95 % confidence intervals. PPV positive predictive value, NPV negative predictive value, DP distributed parameter modeling, MBF myocardial blood flow, MPR myocardial perfusion reserve, MPR 2 myocardial perfusion reserve of the two lowest scoring segments, PV per vessel analysis, PP per patient analysis