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Table 6 Diagnostic performance of Fermi and DP modeling in per vessel and per patient analysis

From: Quantitative assessment of myocardial blood flow in coronary artery disease by cardiovascular magnetic resonance: comparison of Fermi and distributed parameter modeling against invasive methods

Haemodynamic parameter-Model Sensitivity Specificity PPV NPV
Fermi-MBF PV 0.85 (0.76 to 0.94) 0.54 (0.43 to 0.65) 0.51 (0.39 to 0.63) 0.86 (0.74 to 0.98)
DP-MBF PV 0.89 (0.79 to 0.99) 0.63 (0.52 to 0.74) 0.58 (0.48 to 0.68) 0.91 (0.84 to 0.98)
Fermi-MPR PV 0.69 (0.50 to 0.88) 0.54 (0.40 to 0.68) 0.46 (0.32 to 0.60) 0.76 (0.62 to 0.90)
DP-MPR PV 0.85 (0.72 to 0.98) 0.61 (0.48 to 0.74) 0.55 (0.43 to 0.67) 0.88 (0.76 to 1.00)
Fermi-MPR2 PV 0.73 (0.58 to 0.88) 0.65 (0.51 to 0.79) 0.54 (0.40 to 0.68) 0.81 (0.68 to 0.94)
DP-MPR2 PV 0.77 (0.62 to 0.92) 0.70 (0.56 to 0.84) 0.58 (0.46 to 0.70) 0.84 (0.75 to 0.94)
Fermi-MBF PP 0.78 (0.66 to 0.90) 0.88 (0.76 to 1.00) 0.93 (0.86 to 1.00) 0.66 (0.55 to 0.77)
DP-MBF PP 0.96 (0.91 to 1.00) 0.92 (0.85 to 0.99) 0.96 (0.91 to 1.00) 0.92 (0.84 to 1.00)
Fermi-MPR PP 0.69 (0.55 to 0.83) 0.83 (0.70 to 0.96) 0.90 (0.80 to 1.00) 0.58 (0.46 to 0.70)
DP-MPR PP 0.88 (0.76 to 1.00) 0.88 (0.78 to 0.98) 0.94 (0.88 to 1.00) 0.78 (0.66 to 0.90)
Fermi-MPR2 PP 0.80 (0.66 to 0.94) 0.79 (0.62 to 0.94) 0.89 (0.78 to 1.00) 0.66 (0.55 to 0.77)
DP-MPR2 PP 0.92 (0.86 to 0.98) 0.83 (0.74 to 0.92) 0.92 (0.86 to 0.98) 0.83 (0.73 to 0.93)
  1. Parentheses show 95 % confidence intervals. PPV positive predictive value, NPV negative predictive value, DP distributed parameter modeling, MBF myocardial blood flow, MPR myocardial perfusion reserve, MPR 2 myocardial perfusion reserve of the two lowest scoring segments, PV per vessel analysis, PP per patient analysis