Cardiovascular magnetic resonance detects the progression of impaired myocardial perfusion reserve and increased left-ventricular mass in mice fed a high-fat diet

Table 1 CMR parameters of cardiac function

	Time (Weeks after start of diet)
	6 weeks		12 weeks		18 weeks		24 weeks
	Control	HFD	Control	HFD	Control	HFD	Control	HFD
LVEDV (μL)	43 ± 7	42 ± 7	48 ± 9	47 ± 10	44 ± 7	40 ± 7	40 ± 6	43 ± 5
LVESV (μL)	17 ± 4	14 ± 4	17 ± 6	17 ± 6	16 ± 6	12 ± 5	13 ± 4	11 ± 5
LVEF (%)	61 ± 8	66 ± 8	64 ± 12	65 ± 8	64 ± 9	69 ± 12	67 ± 8	74 ± 11
Heart Rate (bpm)	530 ± 63	538 ± 88	478 ± 39	485 ± 69	450 ± 84	512 ± 62	507 ± 47	549 ± 59
Change in Heart Rate under Stress (%)	23 ± 16	28 ± 12	27 ± 5	16 ± 13	15 ± 19	21 ± 13	21 ± 28	−2 ± 15*
E_cc	−0.14 ± 0.02	−0.13 ± 0.02	−0.13 ± 0.02	−0.12 ± 0.01	−0.12 ± 0.03	−0.11 ± 0.02	−0.12 ± 0.01	−0.14 ± 0.02
E_cc-subepi	−0.09 ± 0.01	−0.09 ± 0.02	−0.09 ± 0.01	−0.08 ± 0.01	−0.08 ± 0.02	−0.07 ± 0.02	−0.08 ± 0.01	−0.09 ± 0.01
E_cc-subendo	−0.19 ± 0.02	−0.17 ± 0.03	−0.18 ± 0.03	−0.16 ± 0.02	−0.17 ± 0.04	−0.16 ± 0.03	−0.17 ± 0.02	−0.20 ± 0.03
CURE	0.87 ± 0.06	0.85 ± 0.07	0.90 ± 0.05	0.87 ± 0.05	0.85 ± 0.06	0.89 ± 0.04	0.84 ± 0.04	0.84 ± 0.03

ISSN: 1532-429X