| Controls (n = 7) | DOCA (n = 5) | Controls vs. DOCA | |||||
---|---|---|---|---|---|---|---|---|
Parameter | Rest | Stress | p | Rest | Stress | p | prest | pstress |
Aortic vessel wall and aortic blood velocity | ||||||||
 APV (cm · s−1) | 113 ± 15 | 158 ± 26 | 0.001 | 92 ± 14 | 140 ± 31 | 0.011 | 0.033 | 0.308 |
 AAmean (mm−2) | 3.4 ± 0.4 | 3.7 ± 0.7 | 0.091 | 5.5 ± 0.5 | 5.0 ± 1.3 | 0.244 | < 0.001 | 0.064 |
 AAmin (mm−2) | 2.8 ± 0.4 | 3.0 ± 0.6 | 0.211 | 4.6 ± 0.5 | 4.2 ± 1.1 | 0.229 | < 0.001 | 0.044 |
 AAmax (mm−2) | 4.1 ± 0.4 | 4.5 ± 0.6 | 0.061 | 6.3 ± 0.5 | 5.7 ± 1.4 | 0.228 | < 0.001 | 0.072 |
 AWT (mm) | 1.8 ± 0.3 |  |  | 2.3 ± 0.4 |  |  | 0.039 |  |
Transmitral and myocardial tissue velocities | ||||||||
 E (cm · s−1) | 63 ± 6 | 78 ± 9 | 0.001 | 56 ± 10 | 70 ± 11 | 0.001 | 0.181 | 0.222 |
 A (cm · s−1) | 47 ± 11 | 48 ± 9 | 0.714 | 43 ± 12 | 43 ± 13 | 0.801 | 0.532 | 0.404 |
 E/A | 1.4 ± 0.5 | 1.7 ± 0.5 | 0.100 | 1.4 ± 0.4 | 1.7 ± 0.5 | < 0.001 | 0.861 | 0.886 |
 AT (ms) | 87 ± 17 | 79 ± 9 | 0.329 | 83 ± 14 | 70 ± 9 | 0.091 | 0.639 | 0.120 |
 DT (ms) | 152 ± 50 | 163 ± 66 | 0.705 | 169 ± 67 | 153 ± 16 | 0.639 | 0.622 | 0.760 |
 E’sep (cm · s−1) | 18 ± 4 | 20 ± 6 | 0.743 | 11 ± 3 | 14 ± 2 | 0.109 | 0.010 | 0.069 |
 E’lat (cm · s−1) | 21 ± 5 | 25 ± 6 | 0.346 | 14 ± 3 | 16 ± 3 | 0.213 | 0.067 | 0.019 |
 E’ (cm · s−1) | 20 ± 4 | 23 ± 6 | 0.492 | 13 ± 2 | 15 ± 2 | 0.130 | 0.007 | 0.025 |
 E/E’ | 3.3 ± 0.6 | 3.6 ± 0.7 | 0.185 | 4.4 ± 1.1 | 4.6 ± 0.6 | 0.707 | 0.038 | 0.031 |
 (E/E’)/EDV (10−2 ml−1 · m2) | 2.7 ± 0.5 | 3.1 ± 0.6 | 0.151 | 3.6 ± 0.9 | 4.8 ± 1.6 | 0.112 | 0.035 | 0.030 |
Pulmonary venous velocities | ||||||||
 S1 (cm · s−1) | 33 ± 9 | 48 ± 4 | 0.006 | 39 ± 18 | 46 ± 5 | 0.516 | 0.502 | 0.408 |
 S2 (cm · s−1) | 40 ± 10 | 49 ± 9 | 0.032 | 44 ± 18 | 44 ± 5 | 0.668 | 0.624 | 0.484 |
 D (cm · s−1) | 37 ± 10 | 56 ± 11 | < 0.001 | 57 ± 17 | 58 ± 6 | 0.792 | 0.035 | 0.636 |
 S/D | 1.1 ± 0.2 | 0.9 ± 0.2 | 0.019 | 0.8 ± 0.2 | 0.8 ± 0.2 | 0.864 | 0.045 | 0.194 |
Coronary sinus | ||||||||
 NFVCS (ml · m−2) | 1.6 ± 0.5 | 2.7 ± 1.0 | 0.003 | 2.4 ± 0.6 | 2.8 ± 0.5 | 0.300 | 0.025 | 0.886 |
 GMP (ml · min−1 · g−1) | 1.6 ± 0.4 | 3.7 ± 1.4 | 0.002 | 1.9 ± 0.3 | 2.9 ± 0.5 | 0.029 | 0.197 | 0.268 |
 MPR |  | 2.2 ± 0.5 |  |  | 1.5 ± 0.4 |  |  | 0.028 |