Fig. 1

Structural remodeling in the infarcted heart. A A short-axis slice of a normal heart with left ventricle (LV) segments in blue. The two dashed green lines delineate the control segments. B Visualization of eigenvectors in a section (red box in A) of the anterior wall. Fibers are color-coded based on absolute values of inclinations angles, i.e. blue signifies circumferential fiber orientation. C Short-axis LGE image of an infarcted porcine heart and D the co-registered non-diffusion-weighted image. E The same slice as in C and D but with LV segments and fibrosis mask overlaid in blue and red, respectively. F Zoomed-in view of the red box in (E) highlighting fibrotic and non-fibrotic tissues inside infarcted segments. Green dashed line demarcates infarcted and non-infarcted segments. G Fiber visualization in the region shown in F highlighting the transition from non-infarcted to infarcted tissue, with the color-coding as in B. H Measurement of inclination (inc) and imbrication (imb) angles of primary eigenvector in a local coordinate system (n, t, f) that is tangential to the endocardial surface – see Methods for the definitions