Histological validation of cardiovascular magnetic resonance T1 mapping markers of myocardial fibrosis in paediatric heart transplant recipients

Table 2 Cardiovascular magnetic resonance parameters in patients and volunteers

		Patients	Controls	p
		(n = 20)	(n = 24)	p
Native T1 time, ms	IVS	1008 ± 32	979 ± 24	<0.005
	Entire LV	992 ± 34	974 ± 27	0.06
	Blood	1515 ± 78	1537 ± 55	0.30
ECV	IVS	0.30 ± 0.04	0.22 ± 0.03	<0.0001
ECV	Entire LV	0.29 ± 0.03	0.22 ± 0.03	<0.0001
LVEDVi, ml/m²		79 ± 17	88 ± 11	<0.01
LVESVi, ml/m²		37 ± 11	36 ± 7	0.62
LVEF, %		54 ± 5	59 ± 5	<0.005
LVMM, g/m²		65 ± 16	48 ± 12	<0.0005
LVMM/LVEDVi, g/ml		0.8 ± 0.2	0.5 ± 0.1	<0.0001
RVEDVi, ml/m²		89 ± 19	93 ± 12	0.38
RVESVi, ml/m²		47 ± 13	45 ± 8	0.45
RVEF, %		47 ± 8	52 ± 4	0.06
LV longitudinal strain, %		−13.4 ± 4.3^a	−16.3 ± 4.8^b	0.12
LV longitudinal strain rate, %/s		−1.0 ± 0.3^a	−1.1 ± 0.4^b	0.25
LV circumferential strain, %		−22.1 ± 4.0	−22.3 ± 2.9	0.88
LV circumferential strain rate, %/s		−1.5 ± 0.4	−1.4 ± 0.3	0.21
LV radial strain, %		25.7 ± 11.6	40.5 ± 9.9	<0.0001
LV radial strain rate, %/s		1.3 ± 0.3	1.8 ± 0.4	<0.0005

Data are expressed as mean and standard deviation
Abbreviations: ECV extracellular volume fraction, IVS interventricular septum; LV left ventricle, LVEDV left ventricular end-diastolic volume, LVESV left ventricular end-systolic volume, LVEF left ventricular ejection fractio, LVMM left ventricular muscle mass, RVEDV right ventricular end-diastolic volume, RVESV right ventricular end-systolic volume, RVEF right ventricular ejection fraction
^aData of LV longitudinal strain and strain rate were available in 19 of 20 patients
^bData of LV longitudinal strain and strain rate were available in 9 of 24 controls

ISSN: 1532-429X