Extra-cellular expansion in the normal, non-infarcted myocardium is associated with worsening of regional myocardial function after acute myocardial infarction

Table 2 Baseline and follow-up CMR parameters

	Acute CMR		Follow-up CMR		P-value^a
	Median	25%–75% quartiles	Median	25%–75% quartiles
Baseline CMR characteristics
LVEDVi, ml/m2	79.1	71–87	80.45	70–89	0.41
LVESVi, ml/m2	42	36–50	38.7	31–47	0.02
LV MASSi, grams/m2	55.45	48–64	48.55	43–55	<0.0001
EF, %	45.65	36–51	52.35	43–59	<0.0001
IS, volume in %	23.9	17–38	13.75	9–27	<0.0001
Segmental myocardial tissue composition and function
	Median	25% - 75% Quartiles	Median	25% - 75% Quartiles
Normal ECV, % (n = 325)	27.5	24.8–3 0.5	27.7	25.2–32	0.03
Oedema ECV, % (n = 246)	34	29–39.3	32	28–37	0.0002
Infarct ECV, % (n = 229)	44	37.4–49	41	33.6–46	<0.0001
Normal WT (mm) (n = 325)	3.7	2.7–4.8	3.8	2.0–4.7	0.81
Oedema WT (mm) (n = 246)	2.9	1.8–4.3	3.3	2.4–4.3	0.02
Infarct WT (mm) (n = 229)	1.6	0.47–2.8	2.4	1.1–3.6	<0.0001
Normal EDT (mm)	7.3	6–8	6.7	6–7.5	<0.0001
Oedema EDT (mm)	7.4	6–8.5	6.5	5–7.6	<0.0001
Infarct EDT (mm)	7.9	7–9	6.4	56–7.6	<0.0001
Global myocardial tissue composition
Total LV myocyte volume, mL/m2	51.2	45.7–57.4	53.6	46.3–61	0.14
Total LV extracellular matrix, ml/m2	25.8	22.7–32.8	26.1	21.8–32.8	0.68

LV measurements are indexed to body surface area (BSA), infarct volumes are unindexed. LVEDVi = Left ventricular end-diastolic volume (indexed), LVESVi = Left ventricular end-systolic volume (indexed), LVMi = Left ventricular mass (indexed), RS = peak systolic radial strain (%)
^aWilcoxon test (paired samples)

ISSN: 1532-429X