Table 2 Vasodilator Induced Hemodynamic Changes
Baseline | Immediate Post-VD | 5 min | 10 min | 15 min | Change from Baseline at 15 min p-value | |
|---|---|---|---|---|---|---|
HR, bpm | ||||||
Adenosine | 64 ± 8 | 96 ± 13 | 67 ± 8 | 64 ± 7 | 65 ± 13 | 0.4165 |
Regadenoson | 65 ± 13 | 107 ± 10 | 81 ± 9 | 75 ± 7 | 72 ± 8 | 0.0015 |
Between agent p-value | 0.4165 | <0.0001 | <0.0001 | <0.0001 | <0.0001 | |
SBP, mm Hg | ||||||
Adenosine | 136 ± 16 | 131 ± 22 | 133 ± 18 | 134 ± 15 | 131 ± 24 | 0.1064 |
Regadenoson | 131 ± 24 | 126 ± 17 | 126 ± 19 | 126 ± 19 | 129 ± 20 | 0.5998 |
Between agent p-value | 0.3770 | 0.0780 | 0.7089 | 0.6514 | 0.8289 | |
DBP, mm Hg | ||||||
Adenosine | 69 ± 12 | 69 ± 13 | 64 ± 10 | 65 ± 10 | 67 ± 11 | 0.3770 |
Regadenoson | 67 ± 11 | 65 ± 12 | 63 ± 11 | 64 ± 10 | 67 ± 12 | 0.8289 |
Between agent p-value | 0.3770 | 0.0780 | 0.7089 | 0.6514 | 0.8289 | |
Pulse oximetry, % | ||||||
Adenosine | 98 ± 1 | 98 ± 2 | 98 ± 2 | 98 ± 2 | 98 ± 3 | 0.2204 |
Regadenoson | 98 ± 3 | 98 ± 3 | 98 ± 1 | 98 ± 2 | 98 ± 1 | 0.1503 |
Between agent p-value | 0.2204 | 0.1299 | 0.7449 | 0.7449 | 0.1503 | |
LVEF, % | ||||||
Adenosine | 63.0 ± 4.6 | 69.8 ± 6.8 | 66.6 ± 5.6 | 63.3 ± 5.4 | 63.0 ± 6.9 | 0.9623 |
Regadenoson | 63.0 ± 6.9 | 70.3 ± 5.0 | 69.8 ± 5.3 | 66.9 ± 5.9 | 67.2 ± 4.9 | 0.0015 |
Between agent p-value | 0.9623 | 0.6842 | 0.0146 | 0.0068 | 0.0015 | |
LVEDVi, mL/m2 | ||||||
Adenosine | 71.2 ± 15.6 | 72.9 ± 15.4 | 70.2 ± 17.9 | 67.3 ± 16.0 | 66.3 ± 17.3 | 0.0023 |
Regadenoson | 66.3 ± 17.3 | 64.5 ± 13.8 | 63.0 ± 14.4 | 62.9 ± 14.5 | 62.2 ± 14.9 | 0.0103 |
Between agent p-value | 0.0023 | <0.0001 | <0.0001 | 0.0063 | 0.0103 | |
LVESVi, mL/m2 | ||||||
Adenosine | 26.4 ± 7.0 | 22.0 ± 6.3 | 23.7 ± 8.2 | 24.3 ± 7.9 | 25.6 ± 9.7 | 0.5226 |
Regadenoson | 25.6 ± 9.7 | 19.1 ± 4.9 | 19.1 ± 6.1 | 21.1 ± 6.3 | 20.3 ± 5.5 | <0.0001 |
Between agent p-value | 0.5226 | 0.0136 | 0.0001 | 0.0074 | <0.0001 | |
LVSVi, mL/m2 | ||||||
Adenosine | 44.8 ± 10.1 | 51.0 ± 11.8 | 46.6 ± 11.4 | 43.0 ± 10.4 | 41.9 ± 12.4 | 0.0584 |
Regadenoson | 41.9 ± 12.4 | 45.4 ± 10.5 | 43.9 ± 9.9 | 41.8 ± 9.9 | 41.9 ± 10.9 | 0.9853 |
Between agent p-value | 0.0584 | 0.0003 | 0.0857 | 0.4335 | 0.9853 | |
LV mass index, g/m2 | ||||||
Adenosine | 51.3 ± 9.1 | 56.6 ± 9.4 | 53.4 ± 11.0 | 52.5 ± 10.0 | 52.4 ± 11.3 | 0.4411 |
Regadenoson | 52.4 ± 11.3 | 54.6 ± 10.8 | 53.5 ± 11.3 | 53.3 ± 11.7 | 53.5 ± 10.8 | 0.3937 |
Between agent p-value | 0.4411 | 0.1538 | 0.9063 | 0.5165 | 0.3937 | |
RVEF, % | ||||||
Adenosine | 57.0 ± 7.5 | 61.7 ± 6.9 | 59.1 ± 6.1 | 57.1 ± 7.3 | 58.5 ± 8.2 | 0.2905 |
Regadenoson | 58.5 ± 8.2 | 62.4 ± 6.3 | 63.7 ± 7.1 | 61.9 ± 6.0 | 61.9 ± 7.5 | 0.0159 |
Between agent p-value | 0.2905 | 0.6337 | 0.0014 | 0.0008 | 0.0159 | |
RVEDVi, mL/m2 | ||||||
Adenosine | 74.6 ± 16.7 | 78.3 ± 19.0 | 75.7 ± 18.7 | 72.4 ± 15.3 | 69.9 ± 17.5 | 0.0104 |
Regadenoson | 69.9 ± 17.5 | 70.9 ± 17.1 | 66.4 ± 16.1 | 65.0 ± 14.5 | 66.0 ± 15.1 | 0.0357 |
Between agent p-value | 0.0104 | <0.0001 | <0.0001 | <0.0001 | 0.0357 | |
RVESVi, mL/m2 | ||||||
Adenosine | 32.1 ± 9.4 | 30.2 ± 9.4 | 30.8 ± 8.3 | 31.0 ± 8.1 | 28.7 ± 8.0 | 0.0024 |
Regadenoson | 28.7 ± 8.0 | 26.6 ± 7.3 | 24.1 ± 7.8 | 24.6 ± 7.2 | 24.9 ± 6.7 | 0.0009 |
Between agent p-value | 0.0024 | 0.0015 | <0.0001 | <0.0001 | 0.0009 | |
RVSVi, mL/m2 | ||||||
Adenosine | 42.5 ± 10.8 | 48.1 ± 12.1 | 44.9 ± 12.8 | 41.5 ± 10.7 | 41.2 ± 12.9 | 0.4339 |
Regadenoson | 41.2 ± 12.9 | 44.3 ± 12.1 | 42.3 ± 10.9 | 40.0 ± 9.6 | 41.1 ± 11.5 | 0.9507 |
Between agent p-value | 0.4339 | 0.0240 | 0.1175 | 0.3810 | 0.9507 | |