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Table 2 Clinical, Imaging Characteristics, Treatment and Outcomes of Patients with AS + Cardiac Amyloidosis

From: Cardiac amyloidosis is prevalent in older patients with aortic stenosis and carries worse prognosis

 

Patient 1

Patient 2

Patient 3

Patient 4

Patient 5

Patient 6

Patient 7

Patient 8

Patient 9

ECG Rhythm

AFib

AFib

AFib

AFib

NSR

NSR

S. Tach

AFib

AFib

Low Voltage Criteria

No

No

No

No

No

No

No

No

No

Echocardiographic findings

 IVS/IL Thickness (cm)

2.0/1.9

1.7/1.5

1.7/1.4

1.9/1.5

1.8/1.5

1.9/1.5

1.6/1.6

2.1/1.9

1.6/1.6

 Aortic Valve Area (cm2)

0.3

0.7

0.4

0.9

0.6

0.8

0.6

1.1

0.5

 Mean AV Gradient (mmHg)

18

33

33

13

30

47

37

12

50

 Stroke Volume Index (ml/m2)

16

32

27

22

28

35

14

21

37

CMR Findings

 LV Ejection Fraction (%)

23

45

35

53

35

67

18

49

51

 LV End-Diastolic Vol Index (ml/m2)

104

64

93

60

94

47

91

88

101

 LV Mass Index (g/m2)

101

103

97

113

108

73

84

139

128

 Native T1 (msec)

1127

N/A

1115

1141

1097

1091

1081

1225

N/A

 ECV (%)

70

N/A

40

33

28

35

N/A

46

N/A

Treatment and outcomes

 Aortic Valve Replacement

No

No

TAVR

No

TAVR

No

No

TAVR

TAVR

 Status

Dead

Dead

Dead

Alive

Alive

Alive

Dead

Alive

Dead

 Survival after CMR (months)

1

2

3

6

8

8

3

5

2

  1. IVS interventricular septum thickness, IL inferolateral wall, ECV extracellular volume fraction, N/A Not available. ECG electrocardiogram, TAVR transcather aortic valve replacement