| G+/LVH+ Overt HCM (N = 34) | G+/LVH- Preclinical (N = 24) | G−/LVH- Controls (N = 15) |
P-value overall* |
P-value* Preclinical vs Control |
P-value* HCM vs Preclinical |
P-value* HCM vs Control |
---|
LAV Max/BSA, ml/m2
| 46 ± 18 | 32 ± 12 | 33 ± 9 | 0.031 | 0.83 | 0.050 | 0.13 |
LAV BAC/BSA, ml/m2
| 31 ± 16 | 20 ± 9 | 18 ± 6 |
0.015
| 0.56 | 0.050 | 0.10 |
LAV Min/BSA, ml/m2
| 20 ± 12 | 12 ± 5 | 10 ± 4 | 0.019 | 0.20 | 0.047 | 0.12 |
LAPEmF, % | 35 ± 11 | 41 ± 11 | 47 ± 9 |
0.002
| 0.077 | 0.23 |
0.006
|
LAAEmF, % | 38 ± 11 | 39 ± 5 | 43 ± 9 | 0.033 | 0.060 | 0.46 | 0.074 |
LATEmF, % | 59 ± 10 | 64 ± 8 | 70 ± 7 |
<0.001
|
0.002
| 0.20 |
0.005
|
- LVH was based on echocardiographic core laboratory measurements, defined as a maximal LV wall thickness (LVWT) ≥12 mm in adults or a z-score ≥ 3 in participants <18 years of age. LAV left atrial volume, BAC before atrial contraction, BSA body surface area, LATEmF Total left atrial function, LAPEmF left atrial passive function, LAAEmF left atrial active function. Values represent mean and SD unless otherwise indicated
- *Adjusted for age, gender, BSA and family relationships; P values ≤0.017 were considered to indicate statistical significance, applying Bonferroni correction for multiple comparisons across the three groups