Circulating levels of P-selectin and E-selectin relate to cardiovascular magnetic resonance-derived aortic characteristics in young adults from the general population, a cross-sectional study

Table 1 Relation between circulating endothelial cell adhesion molecules (CAMs) and aortic characteristics

	Aortic wall area (cm²)^b (n = 124)	p value	Aortic wall thickness (mm)^b,d (n = 124)	p value	Aortic PWV (m/s)^b,d (n = 118)	p value
P-selectin (μg/ml)^c
Model 1	0.21 (0.04, 0.38)	0.02§	0.19 (0.06, 0.32)	0.005§	−0.09 (− 0.32, 0.13)	0.41
Model 2	0.14 (−0.02, 0.30)	0.08	0.18 (0.04, 0.31)	0.01§	−0.17 (− 0.39, 0.54)	0.14
E-selectin (μg/ml)^c
Model 1	0.01 (−2.26, 2.28)	0.99	0.26 (−1.46, 1.99)	0.77	3.83 (1.14, 6.53)	0.006§
Model 2	−1.72 (−3.84, 0.39)	0.11	−0.45 (−2.28, 1.39)	0.63	3.01 (0.08, 5.95)	0.04§
ICAM − 1 (μg/ml)^a,c
Model 1	0.15 (−0.02, 0.32)	0.08	0.11 (−0.02, 0.24)	0.08	0.09 (−0.11, 0.30)	0.36
Model 2	0.15 (−0.05, 0.26)	0.18	0.11 (−0.03, 0.24)	0.12	0.02 (−0.24, 0.27)	0.88
VCAM-1 (μg/ml)^a,c
Model 1	0.01 (−0.01, 0.03)	0.36	-1.59 × 10^− 3 (− 0.02, 0.01)	0.85	− 0.01 (− 0.03, 0.01)	0.41
Model 2	−2.03 × 10⁻³ (− 0.02, 0.02)	0.84	−2.73 × 10^− 3 (− 0.02, 0.01)	0.75	−0.01 (− 0.03, 0.01)	0.53

^aPWV pulse wave velocity, ICAM-1 intercellular adhesion molecule, VCAM-1 vascular cell adhesion molecule
^bValues are linear mixed-effects regression coefficients (beta’s, (β)) with 95% confidence intervals
^cModel 1: crude model, Model 2: adjusted for age, sex, BMI, smoking, DBP, HDL-cholesterol and total cholesterol
§ p < 0.05
^dNatural logarithmic transformation was performed

ISSN: 1532-429X