Fig. 4

Comparison of optimal abbreviated acquisition protocols to fully-sampled reference 60 min acquisitions: linear correlations and Bland-Altman plots of biases for the repeated euvolemic conditions. The tested reduced-protocol acquisition points are represented by the orange circles in the left-hand column: Protocol 1 calculates plasma volume (V_plasma) from a single point; the earliest post-contrast administration point. Protocol 2 and Protocol 3 respectively use an early set of successive measurements (5 points) and a reduced set of early measurements and a late ‘anchor’ (4 points) for optimal linear fitting, respectively. Each technique agrees well with the fully sampled dataset, though increased sampling over a longer period improves both bias and correlation