N | Patients: PAH | Group 3 PH LHD | Patients: no PAH | Healthy Subjects |
---|---|---|---|---|
369 | 39 | 82 | 24 | |
Demographics and characteristics | ||||
 Age (years) | 58.2 ± 15.0 | 68.1 ± 12.7** | 55.4 ± 18.3 | 58.1 ± 3.88 |
 Sex (female %) | 66.0 | 59.5 | 67.1 | 50.9 |
Subgroup diagnoses (n) |  | N/A | N/A | – |
Group 1 PAH | n = 223 |  |  |  |
PH-Lung | n = 41 |  |  |  |
 CTEPH | n = 92 |  |  |  |
 PH-MISC | n = 10 |  |  |  |
 BSA (m2) | 1.81 ± 250 | 1.89 ± 0.26 | 1.85 ± 0.25 |  |
CMR | ||||
 Heart Rate (bpm) | 72.17 ± 14.4 | 69.81 ± 3.8 | 67.9 ± 10.3** |  |
 CMR at incident vs prevalent time (incident %) | N = 165 (45%) | N = 31 (80%) | N = 82 (100%) |  |
 RV insertion T1 (ms) | 1065 ± 86 | 1074 ± 10 | 1017 ± 69 | 943 ± 52** |
 Septal T1 (ms) | 975 ± 67 | 986 ± 73 | 976 ± 75 | 940 ± 56* |
 LV free wall T1 (ms) | 965 ± 68 | 982 ± 81 | 961 ± 66 | 913 ± 55** |
 RVEDV Index (ml/m2) | 87.2 ± 34.1 | 81.9 ± 31.7 | 68.0 ± 20.4** |  |
 RVESV Index (ml/m2) | 51.7 ± 29.0 | 45.4 ± 23.1 | 31.1 ± 11.6** |  |
 RVSV Index (%) | 35.6 ± 14.2 | 36.5 ± 12.1 | 36.9 ± 12.9 |  |
 RVEF (%) | 43.1 ± 13.6 | 46.8 ± 11.2 | 54.4 ± 10.0** |  |
 LVEDV Index (ml/m2 | 58.5 ± 16.1 | 68.9 ± 21.2** | 66.6 ± 16.1** |  |
 LVESV Index ml/m2) | 19.2 ± 8.2 | 26.1 ± 16.6** | 21.3 ± 8.2* |  |
 LVSV Index (%) | 39.2 ± 11.9 | 42.8 ± 13.4 | 45.3 ± 10.8** |  |
 LVEF (%) | 67.3 ± 9.7 | 63.8 ± 14.5 | 68.3 ± 7.6 |  |
 Systolic septal angle (°) | 165.5 ± 23.9 | 145.9 ± 15.5 | 150.5 ± 108.4* |  |
 Diastolic septal angle (°) | 143.34 ± 11.0 | 138.3 ± 10.3** | 134.9 ± 7.9* |  |
 RV mass index (g/m2) | 21.9 ± 12.5 | 14.4 ± 5.5** | 11.9 ± 5.8* |  |
 LV mass index (g/m2) | 48.0 ± 12.3 | 57.2 ± 21.1** | 47.7 ± 10.7 |  |
 VMI (ratio) | 0.47 ± 0.27 | 0.28 ± 0.13** | 0.26 ± 0.18* |  |