Machine Learning Derived Aortic Flow in Relation to Cine-CMR LV Stroke Volume. a Correlations between aortic through-plane flow as quantified by fully automated machine learning algorithm and LV volumetric stroke volume as quantified on cine-CMR among patients without advanced (>mild) mitral regurgitation. Note moderate correlation between approaches (left) and non-significant differences in stroke volume (right). b Machine learning aortic flow and cine-CMR stroke volume among patients with advanced (>mild) mitral regurgitation. Note lower transaortic flow as quantified by cine-CMR consistent with decreased forward systemic output in context of mitral regurgitation.