Aminophylline shortage and current recommendations for reversal of vasodilator stress: an ASNC information statement endorsed by SCMR

Table 2 Serious and fatal complications of exercise and pharmacologic cardiac stress testing (rate of observed and reported events per 1000). Reproduced with permission from Dilsizian et al. [3]

	Exercise	Dobutamine	Dipyridamole MPI	Adenosine MPI	Regadenoson MPI	Gadolinium MPI
Any serious complication	0.1–3.46	2.988	0.714–2.6	0.97	Case reports	NR
Death	0–0.25	Case reports	0.5	Case reports	Case reports	NR
VFib/VTach	0–25.7	0.6–1.35	NR	NR	NR	NR
Acute MI	0.038	0.3–3.0	1.0	0.108	Case reports	NR
Cardiac rupture	Unknown	Case reports	NR	NR	NR	NR
High degree AVB or asystole	Unknown	NR	Case reports	Case reports	Case reports	NR
Bronchospasm	Unknown	NR	1.5	0.76	Case reports	NR
Stroke/TIA	Unknown	Case reports	NR	NR	Case reports	NR
AFib	Unknown	5–40	NR	NR	Case reports	NR
Seizure	Unknown	Case reports	NR	1.5	Case reports	NR
CIN	NR	NR	NR	NR	NR	NR
NSF	NR	NR	NR	NR	NR	0–18%^a
Radiation-Induced Cancer	NR	NR	NR (theoretical)	NR (theoretical)	NR (theoretical)	NR

AVB atrioventricular block, AFib atrial fibrillation, CIN contrast induced nephropathy, MI myocardial infarction, NSF nephrogenic systemic fibrosis, NR not reported, TIA transient ischemic attack, VFib ventricular fibrillation, VTach ventricular tachycardia
^aRate of NSF is negligible if not zero in the current era of not administering gadolinium if the estimated glomerular filtration rate is < 30 ml/min/1.74 m²
References for entries are reported in Dilsizian et al. [3]

ISSN: 1532-429X