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Table 3 Unadjusted Cox hazard ratio for the clinical parameters

From: Association of cardiovascular magnetic resonance-derived circumferential strain parameters with the risk of ventricular arrhythmia and all-cause mortality in patients with prior myocardial infarction and primary prevention implantable cardioverter defibrillator

 

Appropriate ICD therapy (30/121)

All-cause mortality without appropriate ICD therapy (23/121)

 

Cox HR (95%CI)

P value

Harrell’s C-statistic

Cox HR (95%CI)

P value

Harrell’s C-statistic

Age, per + 1 year

1.0 (1.0, 1.0)

0.785

0.49

1.0 (1.0, 1.1)

0.353

0.50

Men

3.5 (0.8, 15)

0.086

0.57

2.8 (0.7, 12)

0.164

0.57

Smoking

1.1 (0.5, 2.3)

0.882

0.51

1.4 (0.6, 3.4)

0.449

0.55

Hypertension

0.6 (0.3, 1.3)

0.193

0.54

0.7 (0.3, 1.8)

0.543

0.53

Hypercholesterolemia

1.0 (0.4, 2.2)

0.958

0.50

1.0 (0.4, 2.5)

0.941

0.50

Diabetes mellitus

0.4 (0.1, 1.4)

0.154

0.56

2.2 (1.0, 5.2)

0.062

0.59

Renal failure

2.3 (1.1, 5.0)

0.028

0.58

2.5 (1.1, 6.0)

0.038

0.59

Atrial fibrillation

1.2 (0.5, 2.9)

0.636

0.53

1.5 (0.6, 3.7)

0.426

0.53

Left bundle branch block

1.1 (0.5, 2.3)

0.789

0.52

0.8 (0.3, 2.0)

0.689

0.52

QRS > 120 ms

1.5 (0.7, 3.3)

0.249

0.56

2.3 (1.0, 5.2)

0.051

0.58

CRT device

1.1 (0.5, 2.6)

0.825

0.51

1.3 (0.5, 3.3)

0.661

0.49

NYHA III-IV

1.8 (0.9, 3.7)

0.113

0.58

3.0 (1.3, 6.9)

0.012

0.62

NYHA IV

1.3 (0.2, 9.7)

0.785

0.51

5.6 (1.7, 18)

0.004

0.56

Acute revascularization

0.3 (0.1, 0.7)

0.003

0.65

0.6 (0.2, 1.3)

0.185

0.54

Multi-vessel disease

2.8 (1.0, 7.2)

0.040

0.61

12 (1.7, 92)

0.014

0.65

Prior CABG

1.2 (0.6, 2.5)

0.628

0.53

1.6 (0.7, 3.7)

0.251

0.53

Medication

 Statins

0.8 (0.3, 2.0)

0.621

0.62

4.1 (0.5, 30)

0.170

0.56

 ACE inhibitor

0.6 (0.3, 1.2)

0.116

0.57

2.9 (0.9, 10)

0.081

0.59

 Aldosterone antagonist

0.9 (0.4, 1.9)

0.729

0.50

0.8 (0.3, 2.1)

0.678

0.55

 Amiodarone

1.3 (0.4, 3.6)

0.666

0.52

–

  

 ARB

1.1 (0.4, 2.6)

0.867

0.50

0.5 (0.1, 2.0)

0.308

0.54

 Beta blocker

1.1 (0.4, 3.1)

0.903

0.49

0.7 (0.2, 2.1)

0.552

0.52

 Calcium channel blocker

1.5 (0.5, 5.1)

0.476

0.52

–

 

0.53

 Any diuretic

1.3 (0.6, 2.9)

0.456

0.53

1.1 (0.4, 2.6)

0.882

0.47

  1. Abbreviations as in Table 1. The discriminative performance of each parameter for appropriate ICD therapy or all-cause mortality without appropriate ICD therapy is indicated by the Harrell’s C-statistic (no, good, excellent and perfect discriminative ability is indicated by a C-statistic of 0.5, > 0.7, > 0.8 and 1, respectively). Note: none of the patients who died during follow-up without having received appropriate ICD therapy used amiodarone or calcium channel blockers
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Journal of Cardiovascular Magnetic Resonance

ISSN: 1532-429X

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