Fig. 1
Examples of axial scout CMR (left) and two of the four FAST saturation transfer spectra (right) [19] from a single section in the anterior myocardium (yellow bars on CMR, left panel) of a healthy subject [6] (a); a patient with a dilated cardiomyopathy (DCM) and NYHA Class III heart failure (HF) [6] (b); one with anterior myocardial infarction (MI) and no HF [21] (c); and one with hypertrophic cardiomyopathy (HCM) and NYHA Class I HF[22] (d). Red arrows on the spectra denote the location of saturating irradiation which causes changes in the phosphocreatine (PCr) peak proportional to the creatine kinase (CK) pseudo first-order reaction rate, kf (green triangles, no-HF; orange triangles, HF). In the absence of saturating radiation the PCr and adenosine triphosphate (ATP) signals are proportional to the concentrations, [PCr] and [ATP] which are measured with a reference concentration. For these subjects the 31P CK metabolic parameters of [PCr] in μmol/g, [ATP] in μmol/g, CK flux in µmol/g/sec and kf in sec-1 were (12, 4.3, 3.3, 0.27), (8.5,6.9, 2.5, 0.29), (6.9, 4.2, 2.7, 0.39), and (6.1, 4.3, 2.8, 0.47) respectively