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Table 3 Univariate and multivariate analysis using Cox regression hazards model

From: The amount of late gadolinium enhancement outperforms current guideline-recommended criteria in the identification of patients with hypertrophic cardiomyopathy at risk of sudden cardiac death

Univariate analysis

Multivariate analysis

 

HR (95% CI)

p-value

Model

HR (95% CI)

p-value

Age

0.996 (0.970–1.023)

0.783

Base model

Male

0.638 (0.281–1.446)

0.282

 LGE%

1.081 (1.044–1.120)

<  0.001

Known AF

3.299 (1.425–7.637)

0.005

 Known AF

2.421 (0.903–6.490)

0.079

Unexplained syncope

0.926 (0.274–3.131)

0.901

 LVEF

1.006 (0.951–1.064)

0.844

Family history of SCD

0.711 (0.236–2.682)

0.711

 Left atrial size

1.036 (0.974–1.102)

0.259

NSVT

2.134 (0.903–5.042)

0.084

 NSVT

1.121 (0.441–2.848)

0.810

Left atrial size

1.060 (1.016–1.105)

0.007

With HCM Risk-SCD

LVOTO

1.004 (0.992–1.015)

0.516

 HCM Risk-SCD

0.970 (0.866–1.086)

0.596

LVM > 30 mm

1.194 (0.516–2.763)

0.679

 LGE%

1.087 (1.053–1.123)

< 0.001

LVMi

1.003 (0.995–1.011)

0.478

With ACCF/AHA

LVEF

0.951 (0.903–1.002)

0.057

  ‘ICD not recommended’

reference

LGE%

1.083 (1.052–1.116)

< 0.001

  ‘ICD can be useful’

1.971 (0.664–5.847)

0.221

HCM Risk-SCD

1.034 (0.944–1.132)

0.476

  ‘ICD reasonable’

0.966 (0.354–2.636)

0.946

ACCF/AHA

 LGE%

1.082 (1.049–1.117)

< 0.001

  ‘ICD not recommended’

reference

   

  ‘ICD can be useful’

3.053 (1.058–8.809)

0.039

   

  ‘ICD reasonable’

1.698 (0.652–4.422)

0.278

   
  1. ACCF/AHA American College of Cardiology Foundation / American Heart Association, AF atrial fibrillation, HCM Risk-SCD hypertrophic cardiomyopathy sudden cardiac death risk tool, ICD implantable cardiac defibrillator, LGE late gadolinium enhancement, LVEF left ventricular ejection fraction, LVMi left ventricular mass, indexed to body surface area, LVOTO left ventricular outflow tract obstruction, NSVT non-sustained ventricular tachycardia at Holter monitoring, SCD sudden cardiac death