Table 1 Demographics and cardiovascular magnetic resonance (CMR) data of patients with light-chain amyloidosis (n = 74), with and without reaching the composite endpoints during the follow-up of 2 years
CMR Data | All (n = 74) | Transplant-free survivors (n = 35) | Composite endpoint (death or heart transplantation) (n = 39) | p-Value (between transplant free survivors and composite endpoint) |
|---|---|---|---|---|
Age (years) | 58.5 ± 10.8 | 58.2 ± 9.8 | 58.7 ± 11.7 | 0.84 |
BMI (kg/m2) | 25.9 ± 4.5 | 26.4 ± 4.8 | 25.5 ± 4.2 | 0.4 |
Male gender, n (%) | 50 (67.6) | 21 (60) | 29 (74.4) | 0.2 |
Cardiovascular risk factors, n (%) | ||||
Arterial hypertension | 26 (35) | 11 (31.4) | 16 (41) | 0.31 |
Dyslipidemia | 10 (13.5) | 6 (17.1) | 4 (44) | 0.45 |
Diabetes mellitus | 7 (9.5) | 5 (14.3) | 2 (5.1) | 0.27 |
Smoking | 12 (16.2) | 5 (14.3) | 7 (17.9) | 0.67 |
Family history of sudden cardiac death | 4 (5.4) | 1 (2.9) | 3 (7.7) | 0.4 |
Clinical data | ||||
NYHA class, n (%) | 0.03 | |||
I | 15 (20.3) | 11 (31.4) | 4 (10.2) | |
II | 23 (31.1) | 12 (34.3) | 11 (28.2) | |
III | 36 (48.6) | 12 (34.3) | 24 (61.5) | |
Karnofsky index | 79.5 ± 11.5 | 84.6 ± 7.6 | 74.9 ± 12.5 | < 0.001 |
Laboratory data | ||||
Lambda restricted pts. | 60 (81.1) | 26 (74.3) | 34 (81.2) | 0.3 |
Kappa restricted pts. | 14 (18.9) | 9 (25.7) | 5 (12.8) | 0.29 |
dFLC (mg/dL) | 222.3 ± 110 | 108.9 ± 77.9 | 321.2 ± 197.3 | < 0.001 |
MDRD (mL/min/1.73m2) | 68.3 ± 24.7 | 71.1 ± 23.7 | 65.7 ± 25.9 | 0.36 |
Positive Troponin, n (%) | 53 (71.6) | 19 (54.3) | 34 (87.2) | 0.002 |
ln NT-pro BNP | 7.6 ± 1.8 | 6.4 ± 1.9 | 8.4 ± 1.2 | < 0.001 |
CMR Data | ||||
LAS (%) | −8.4 ± 3.7 | −10 ± 3.7 | −6.9 ± 3.2 | < 0.001 |
MCF (%) | 54.9 ± 26.2 | 69.3 ± 27.5 | 42 ± 15.7 | < 0.001 |
LVEDVI (ml/m2) | 72.2 ± 18.7 | 72.6 ± 19.1 | 71.8 ± 18.6 | 0.89 |
LVESVI (ml/m2) | 32.5 ± 14 | 28.8 ± 11.6 | 35.9 ± 15.2 | 0.03 |
LVEF (%) | 55.6 ± 11.9 | 60.5 ± 11.5 | 51.2 ± 10.7 | < 0.001 |
LVMI (g/m2) | 84.8 ± 29 | 71.5 ± 20.2 | 96.8 ± 30.7 | 0.014 |
GLS (%) | −13.7 ± 5.5 | −15.4 ± 5.9 | − 12.2 ± 4.7 | 0.011 |
Basal longitudinal strain (%) | −12.8 ± 10.7 | −14.3 ± 11.9 | −11.5 ± 9.5 | 0.27 |
Midwall longitudinal strain (%) | −17.2 ± 11.7 | −18.3 ± 12.7 | −16.2 ± 10.8 | 0.46 |
Apical longitudinal strain (%) | −22.4 ± 11.1 | −23.1 ± 12 | −21.8 ± 10.2 | 0.63 |