Healthy Subjects | Marfan patients | ||||||
---|---|---|---|---|---|---|---|
ALL | Non-dilated Marfan | Dilated Marfan | |||||
N | 48 | 75 | p-values | 20 | p-values | 55 | p-values |
age [years] | 39 ± 12 | 37 ± 13 | 0.327 | 34 ± 10 | 0.104 | 38 ± 14 | 0.611 |
Sex [N, (%) men] | 31 (65) | 42 (56) | 0.026 | 5 (25) | 0.002 | 37 (67) | 0.165 |
Height [cm] | 172 ± 8 | 180 ± 11 | < 0.001 | 177 ± 9 | 0.024 | 182 ± 11 | < 0.001 |
BSA [m2] | 1.84 ± 0.16 | 1.91 ± 0.22 | 0.052 | 1.85 ± 0.22 | 0.931 | 1.95 ± 0.22 | 0.011 |
SBP [mmHg] | 126 ± 18 | 128 ± 17 | 0.523 | 130 ± 15 | 0.381 | 128 ± 18 | 0.704 |
DBP [mmHg] | 70 ± 12 | 74 ± 12 | 0.069 | 76 ± 11 | 0.051 | 74 ± 12 | 0.176 |
AoV regurgitant fraction [%] | 1 ± 1 | 2 ± 5 | 0.087 | 1 ± 1 | 0.593 | 3 ± 5 | 0.035 |
AoV peak velocity [m/s] | 1.2 ± 0.2 | 1.1 ± 0.2 | 0.067 | 1.1 ± 0.2 | 0.057 | 1.1 ± 0.3 | 0.122 |
Aortic root diameter [mm] | 30.0 ± 4.0 | 38.6 ± 5.0 | < 0.001 | 34.0 ± 3.1 | < 0.001 | 40.3 ± 4.7 | < 0.001 |
Aortic root z-score | −0.73 ± 1.06 | 2.32 ± 1.99 | < 0.001 | 0.69 ± 0.94 | < 0.001 | 2.88 ± 1.79 | < 0.001 |
AAo diameter [mm] | 30.2 ± 4.1 | 35.2 ± 6.4 | < 0.001 | 30.1 ± 6.1 | 0.958 | 37.1 ± 5.8 | < 0.001 |
Proximal DAo diameter [mm] | 23.2 ± 2.9 | 25.1 ± 4.4 | 0.009 | 22.2 ± 2.1 | 0.174 | 26.2 ± 4.5 | < 0.001 |
AAo PWV [m/s] | 5.3 ± 1.9 | 7.3 ± 2.8 | < 0.001 | 7.1 ± 2.2 | 0.002 | 7.3 ± 3.0 | < 0.001 |
DAo PWV [m/s] | 7.2 ± 2.2 | 10.8 ± 4.5 | < 0.001 | 10.2 ± 4.0 | < 0.001 | 11.1 ± 4.6 | < 0.001 |