Skip to main content

Table 1 Demographics and clinical data

From: Decreased rotational flow and circumferential wall shear stress as early markers of descending aorta dilation in Marfan syndrome: a 4D flow CMR study

 

Healthy Subjects

Marfan patients

ALL

Non-dilated Marfan

Dilated Marfan

N

48

75

p-values

20

p-values

55

p-values

age [years]

39 ± 12

37 ± 13

0.327

34 ± 10

0.104

38 ± 14

0.611

Sex [N, (%) men]

31 (65)

42 (56)

0.026

5 (25)

0.002

37 (67)

0.165

Height [cm]

172 ± 8

180 ± 11

< 0.001

177 ± 9

0.024

182 ± 11

< 0.001

BSA [m2]

1.84 ± 0.16

1.91 ± 0.22

0.052

1.85 ± 0.22

0.931

1.95 ± 0.22

0.011

SBP [mmHg]

126 ± 18

128 ± 17

0.523

130 ± 15

0.381

128 ± 18

0.704

DBP [mmHg]

70 ± 12

74 ± 12

0.069

76 ± 11

0.051

74 ± 12

0.176

AoV regurgitant fraction [%]

1 ± 1

2 ± 5

0.087

1 ± 1

0.593

3 ± 5

0.035

AoV peak velocity [m/s]

1.2 ± 0.2

1.1 ± 0.2

0.067

1.1 ± 0.2

0.057

1.1 ± 0.3

0.122

Aortic root diameter [mm]

30.0 ± 4.0

38.6 ± 5.0

< 0.001

34.0 ± 3.1

< 0.001

40.3 ± 4.7

< 0.001

Aortic root z-score

−0.73 ± 1.06

2.32 ± 1.99

< 0.001

0.69 ± 0.94

< 0.001

2.88 ± 1.79

< 0.001

AAo diameter [mm]

30.2 ± 4.1

35.2 ± 6.4

< 0.001

30.1 ± 6.1

0.958

37.1 ± 5.8

< 0.001

Proximal DAo diameter [mm]

23.2 ± 2.9

25.1 ± 4.4

0.009

22.2 ± 2.1

0.174

26.2 ± 4.5

< 0.001

AAo PWV [m/s]

5.3 ± 1.9

7.3 ± 2.8

< 0.001

7.1 ± 2.2

0.002

7.3 ± 3.0

< 0.001

DAo PWV [m/s]

7.2 ± 2.2

10.8 ± 4.5

< 0.001

10.2 ± 4.0

< 0.001

11.1 ± 4.6

< 0.001

  1. Demographic characteristics, aortic diameters and ascending and descending pulse wave velocities (PWV) of healthy volunteers (HV), Marfan patients (ALL MFS) and the subset of Marfan patients with neither aortic root nor descending aorta dilation (Non-dilated Marfan). SBP, DBP: systolic and diastolic blood pressure, respectively. AAo represents ascending and DAo descending aorta. Data are presented as mean ± SD or number (percentage). P-values report the comparison with healthy controls