Fig. 1

Panels A-H illustrate the method for using cardiovascular magnetic resonance (CMR) flow measurements to measure pulmonary blood volume variation (PBVV) for both lungs combined (a, c, e, g), and separately as represented by the right lung (b, d, f, h), in a representative subject. All plots show a given measure in relation to time during the cardiac cycle. Panels A and B show blood flow in the main pulmonary artery and right pulmonary artery, respectively. Panels c and d show total pulmonary venous flow and right pulmonary venous flow, respectively. Panels e and f show difference between arterial and venous flow for each time frame, indicating the net inflow and outflow, respectively, to or from the pulmonary circulation for each time frame. Panel g and show the cumulative integral of the difference in blood flow from panels e and f over time, corresponding to the change in pulmonary blood volume in both lungs and the right lung, respectively, over one cardiac cycle. The vertical arrow shows the PBVV in ml