|
Variable [units]
|
Week 0
|
Week 4
|
|---|
|
SHAM
|
TAC
|
SHAM
|
TAC
|
p-value
|
|---|
|
ED IVS [mm]
|
0.98 ± 0.02
|
0.98 ± 0.03
|
1.15 ± 0.02
|
1.47 ± 0.03
|
< 0.001*
|
|
ED LVID [mm]
|
7.03 ± 0.12
|
6.90 ± 0.13
|
7.80 ± 0.19
|
8.13 ± 0.22
|
0.30
|
|
ED LVPW [mm]
|
1.33 ± 0.02
|
1.38 ± 0.04
|
1.50 ± 0.07
|
2.00 ± 0.12
|
< 0.01*
|
|
ED AoP [mmHg]
|
–
|
–
|
85 ± 2
|
77 ± 4
|
0.11
|
|
ES IVS [mm]
|
1.36 ± 0.06
|
1.29 ± 0.06
|
1.51 ± 0.10
|
1.80 ± 0.11
|
0.10
|
|
ES LVID [mm]
|
3.93 ± 0.07
|
3.86 ± 0.09
|
4.45 ± 0.15
|
5.09 ± 0.21
|
< 0.05*
|
|
ES LVPW [mm]
|
2.32 ± 0.06
|
2.21 ± 0.05
|
2.53 ± 0.10
|
2.94 ± 0.12
|
< 0.05*
|
|
ES AoP [mmHg]
|
–
|
–
|
118 ± 3
|
186 ± 11
|
< 0.001*
|
|
FS [%]
|
44 ± 1
|
44 ± 1
|
43 ± 1
|
37 ± 1
|
< 0.01*
|
|
EF [%]
|
81 ± 1
|
81 ± 1
|
79 ± 1
|
72 ± 2
|
< 0.01*
|
|
CO [L/min]
|
0.22 ± 0.01
|
0.22 ± 0.01
|
0.29 ± 0.02
|
0.28 ± 0.02
|
0.92
|
|
BW [g]
|
209 ± 5
|
204 ± 4
|
334 ± 8
|
324 ± 6
|
0.36
|
|
HW [g]
|
–
|
–
|
1.14 ± 0.02
|
1.59 ± 0.04
|
< 0.001*
|
|
HW/BW [g/kg]
|
–
|
–
|
3.42 ± 0.05
|
4.91 ± 0.15
|
< 0.001*
|
- Structural and functional measurements before and at 4 weeks post-surgery in TAC and SHAM groups. All measurements are from echocardiograms, with the exception of AoP, BW, HW, and HW/BW, which were measured at the time of excision. Abbreviations: ED end-diastole, ES end-systole, IVS interventricular septum thickness, LVID left ventricular internal diameter, LVPW left ventricular posterior wall thickness, AoP aortic pressure, FS fractional shortening, EF ejection fraction, CO cardiac output, BW body weight, HW wet heart weight. *p < 0.05
