Variable [units] | Week 0 | Week 4 | |||
---|---|---|---|---|---|
SHAM | TAC | SHAM | TAC | p-value | |
ED IVS [mm] | 0.98 ± 0.02 | 0.98 ± 0.03 | 1.15 ± 0.02 | 1.47 ± 0.03 | < 0.001* |
ED LVID [mm] | 7.03 ± 0.12 | 6.90 ± 0.13 | 7.80 ± 0.19 | 8.13 ± 0.22 | 0.30 |
ED LVPW [mm] | 1.33 ± 0.02 | 1.38 ± 0.04 | 1.50 ± 0.07 | 2.00 ± 0.12 | < 0.01* |
ED AoP [mmHg] | – | – | 85 ± 2 | 77 ± 4 | 0.11 |
ES IVS [mm] | 1.36 ± 0.06 | 1.29 ± 0.06 | 1.51 ± 0.10 | 1.80 ± 0.11 | 0.10 |
ES LVID [mm] | 3.93 ± 0.07 | 3.86 ± 0.09 | 4.45 ± 0.15 | 5.09 ± 0.21 | < 0.05* |
ES LVPW [mm] | 2.32 ± 0.06 | 2.21 ± 0.05 | 2.53 ± 0.10 | 2.94 ± 0.12 | < 0.05* |
ES AoP [mmHg] | – | – | 118 ± 3 | 186 ± 11 | < 0.001* |
FS [%] | 44 ± 1 | 44 ± 1 | 43 ± 1 | 37 ± 1 | < 0.01* |
EF [%] | 81 ± 1 | 81 ± 1 | 79 ± 1 | 72 ± 2 | < 0.01* |
CO [L/min] | 0.22 ± 0.01 | 0.22 ± 0.01 | 0.29 ± 0.02 | 0.28 ± 0.02 | 0.92 |
BW [g] | 209 ± 5 | 204 ± 4 | 334 ± 8 | 324 ± 6 | 0.36 |
HW [g] | – | – | 1.14 ± 0.02 | 1.59 ± 0.04 | < 0.001* |
HW/BW [g/kg] | – | – | 3.42 ± 0.05 | 4.91 ± 0.15 | < 0.001* |