Progression and regression of left ventricular hypertrophy and myocardial fibrosis in a mouse model of hypertension and concomitant cardiomyopathy

Table 2 Univariable and multivariable linear regression analysis to examine association of variables with LV ejection fraction after 6 weeks of pressure overload

Variables	Univariable		Multivariable – Model 1 (included early ECV% change) R-Sq = 0.62		Multivariable – Model 2 (included ECV% at 6 weeks) R-Sq =0.54
	Relative change in LVEF (95% CI)	P- value	Relative change in LVEF (95% CI)	P- value	Relative change in LVEF (95% CI)	P- value
MAP, per 5 mmHg	−2.8 (−5.4- -0.1)	0.04	−1.3 (3.0–0.4)	0.23	−1.9 (−3.9–0.1)	0.11
LV mass, per 1 mg	0.1 (−0.05–0.3)	0.08	−0.2 (−0.5–0.1)	0.27	0.2 (−0.1–0.5)	0.21
Early change in ECV%, per 1%	− 2.1 (− 2.9- -1.3)	< 0.001	−2.2 (− 2.9- -1.5)	< 0.001
ECV%	− 1.6 (− 2.3- -0.8)	< 0.001			−1.5 (− 2.2 - -0.7)	< 0.001

ECV% – extracellular volume fraction, LVEF – left ventricular ejection fraction, MAP – mean arterial pressure

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