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Table 3 Comparison of cardiac magnetic resonance imaging findings between the sarcomere gene and mitochondria-related gene mutation groups

From: Effect of sarcomere and mitochondria-related mutations on myocardial fibrosis in patients with hypertrophic cardiomyopathy

  No pathogenic or likely pathogenic variant group (n = 67) Only mitochondria-related nDNA or mtDNA variant groupa (n = 24) Only sarcomere gene variant group (n = 36) Sarcomere and mitochondria-related gene variant groupa (n = 5) P
Late gadolinium enhancement (LGE)      
Presence of LGE in left ventricle 42 (61) 12 (50) 32 (89) 5 nn 0.003
Number of LGE segments in left ventricle 2.9 ± 3.3 2.6 ± 3.8 5.0 ± 2.9**,†† 4.2 ± 1.1 0.012
% LGE amount of left ventricle 6.4 ± 7.8 8.1 ± 13.0 10.9 ± 10.7* 8.3 ± 3.6 0.184
LGE in anteroseptal segments, % 20.9 ± 24.9 17.7 ± 28.1 47.2 ± 27.2**,†† 40.0 ± 5.6  < 0.001
LGE in septal segments, % 18.2 ± 24.8 15.0 ± 27.8 48.3 ± 31.5**,†† 44.0 ± 16.7*,††  < 0.001
LGE in inferoposterior segments, % 12.8 ± 23.8 15.0 ± 27.2 7.8 ± 14.6 8.0 ± 17.9 0.826
LGE in lateral segments, % 15.2 ± 25.4 11.7 ± 22.0 17.2 ± 20.9 12.0 ± 17.9 0.580
LGE in apical segments, % 28.4 ± 37.7 28.1 ± 35.6 37.5 ± 39.4 25.0 ± 25.0 0.643
Extracellular volume fraction (ECV), %      
ECV average of 16 segments 31.5 ± 4.3 30.9 ± 4.5 34.0 ± 5.0*,† 35.4 ± 3.4 0.013
ECV in anteroseptal segments 31.9 ± 4.2 31.4 ± 5.0 35.6 ± 7.0**,†† 36.9 ± 5.2*,† 0.002
ECV in septal segments 31.6 ± 3.9 30.7 ± 4.8 35.6 ± 6.9**,†† 36.8 ± 5.8*,†  < 0.001
ECV in inferoposterior segments 31.0 ± 4.6 30.2 ± 4.0 32.4 ± 4.1 34.8 ± 2.7 0.065
ECV in lateral segments 30.9 ± 5.2 30.0 ± 4.8 31.7 ± 4.1 32.4 ± 1.8 0.544
ECV in apical segments 33.7 ± 5.2 33.7 ± 6.4 35.3 ± 4.8 35.5 ± 4.3 0.500
  1. One patient was missed due to non-analysis of mtDNA
  2. aPathogenic or likely pathogenic mitochondria-related nDNA mutations or damaging mtDNA variants
  3. *P < 0.05
  4. **P < 0.01 versus no pathogenic or likely pathogenic variant group
  5. P < 0.05
  6. ††P < 0.01 versus mitochondria-related variant group