Table 3 Comparison of cardiac magnetic resonance imaging findings between the sarcomere gene and mitochondria-related gene mutation groups
No pathogenic or likely pathogenic variant group (n = 67) | Only mitochondria-related nDNA or mtDNA variant groupa (n = 24) | Only sarcomere gene variant group (n = 36) | Sarcomere and mitochondria-related gene variant groupa (n = 5) | P | |
|---|---|---|---|---|---|
Late gadolinium enhancement (LGE) | |||||
Presence of LGE in left ventricle | 42 (61) | 12 (50) | 32 (89) | 5 nn | 0.003 |
Number of LGE segments in left ventricle | 2.9 ± 3.3 | 2.6 ± 3.8 | 5.0 ± 2.9**,†† | 4.2 ± 1.1 | 0.012 |
% LGE amount of left ventricle | 6.4 ± 7.8 | 8.1 ± 13.0 | 10.9 ± 10.7* | 8.3 ± 3.6 | 0.184 |
LGE in anteroseptal segments, % | 20.9 ± 24.9 | 17.7 ± 28.1 | 47.2 ± 27.2**,†† | 40.0 ± 5.6† | < 0.001 |
LGE in septal segments, % | 18.2 ± 24.8 | 15.0 ± 27.8 | 48.3 ± 31.5**,†† | 44.0 ± 16.7*,†† | < 0.001 |
LGE in inferoposterior segments, % | 12.8 ± 23.8 | 15.0 ± 27.2 | 7.8 ± 14.6 | 8.0 ± 17.9 | 0.826 |
LGE in lateral segments, % | 15.2 ± 25.4 | 11.7 ± 22.0 | 17.2 ± 20.9 | 12.0 ± 17.9 | 0.580 |
LGE in apical segments, % | 28.4 ± 37.7 | 28.1 ± 35.6 | 37.5 ± 39.4 | 25.0 ± 25.0 | 0.643 |
Extracellular volume fraction (ECV), % | |||||
ECV average of 16 segments | 31.5 ± 4.3 | 30.9 ± 4.5 | 34.0 ± 5.0*,† | 35.4 ± 3.4† | 0.013 |
ECV in anteroseptal segments | 31.9 ± 4.2 | 31.4 ± 5.0 | 35.6 ± 7.0**,†† | 36.9 ± 5.2*,† | 0.002 |
ECV in septal segments | 31.6 ± 3.9 | 30.7 ± 4.8 | 35.6 ± 6.9**,†† | 36.8 ± 5.8*,† | < 0.001 |
ECV in inferoposterior segments | 31.0 ± 4.6 | 30.2 ± 4.0 | 32.4 ± 4.1 | 34.8 ± 2.7† | 0.065 |
ECV in lateral segments | 30.9 ± 5.2 | 30.0 ± 4.8 | 31.7 ± 4.1 | 32.4 ± 1.8 | 0.544 |
ECV in apical segments | 33.7 ± 5.2 | 33.7 ± 6.4 | 35.3 ± 4.8 | 35.5 ± 4.3 | 0.500 |