Fig. 3

Myocardial perfusion deficits in HCM mice. a Representative MBF maps showing end-diastolic (upper row) and end-systolic (lower row) cardiac phases for a mid-ventricular SAX views in both male and female control B6 and HCM (D2) mouse heart. MBF maps were acquired using cineALS CMR which facilitates the monitoring of dynamic MBF changes in the cardiac cycles. No sex difference in dynamic MBF changes in the cardiac cycles was observed between groups (B6 male n = 5, B6 female n = 5, D2 male n = 5, D2 female n = 5). Data are shown as the mean ± SD. b Mean MBF were calculated for region of interest (ROI, depicted in orange colour by manually traced endocardial and epicardial contours) in mid-ventricular end-diastole and end-systole in all control (B6) and HCM (D2) mice (n = 10 for each group). Data are shown as the mean ± SD. **p < 0.01, ***p < 0.001 using one-way ANOVA with Tukey’s multiple-comparisons test. (c) Negative Spearman’s rank correlations were seen between left ventricular thickness and myocardial blood flow (n = 16)