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Table 2 Serial Changes in RV LGE and Functional Parameters

From: Longitudinal changes in extent of late gadolinium enhancement in repaired Tetralogy of Fallot: a retrospective analysis of serial CMRs

 

Initial CMR

Latest CMR

p-value

Group 1 (n = 84)

 RVEDVI (ml/m2)

134.5 (114.0, 150.0)

133.9 (117.1, 152.1)

0.013

 RVESVI (ml/ m2)

65.7 (55.1, 81.3)

72.0 (60.8, 84.9)

 < 0.001

 RVEF (%)

49.3 (45.8, 54.8)

47.6 (41.4, 51.5)

 < 0.001

 PR fraction (%)

29.0 (7.0, 40.0)

33.0 (9.0, 43.0)

0.002

 RV LGE score

4 (3, 5)

3 (2,4)

 < 0.001

 RV LGE extent (%)

5.5 (3.4, 8.0)

3.1 (2.0, 4.6)

 < 0.001

 RV Mass/BSA, g/m2

16.6 (14.0, 19.4)

16.6 (14.7, 19.0)

0.652

 RV Mass:Volume, g/ml

0.12 (0.10, 0.16)

0.12 (0.10, 0.15)

0.318

Group 2 (n = 43)

 RVEDVI (ml/m2)

175.7 (141.6, 200.4)

118.7 (102.2, 144.3)

 < 0.001

 RVESVI (ml/ m2)

85.6 (67.8, 106.1)

63.8 (51.5, 82.8)

 < 0.001

 RVEF (%)

50.1 (42.7, 55.0)

46.0 (40.7, 50.5)

0.013

 PR fraction (%)

46.0 (30.0, 55.0)

5.0 (0.0, 13.0)

 < 0.001

 RV LGE score

4 (2, 5)

3 (2, 4)

0.030

 RV LGE extent (%)

4.4 (2.7, 7.7)

3.9 (2.6, 6.3)

0.009

 RV Mass/BSA, g/m2

19.1 (14.9, 22.5)

14.7 (12.5, 16.8)

 < 0.001

 RV Mass:Volume, g/ml

0.11 (0.09, 0.12)

0.12 (0.09, 0.14)

0.018

  1. Variables are expressed as median (interquartile range). Group 1—patients with no interventions between serial CMRs; Group 2—patients with transcatheter or surgical interventions between CMRs. Median time between initial and latest CMR was 4.3 years (IQR 2.9, 6.6) for Group 1, and 2.7 years (IQR 1.6 to 5.3) for Group 2). BSA body surface area, CMR cardiovascular magnetic resonance, EDVI end-diastolic volume index, ESVI end-systolic volume index, EF ejection fraction, PR pulmonary regurgitation, LGE late gadolinium enhancement, RV right ventricle