Adverse fibrosis remodeling and aortopulmonary collateral flow are associated with poor Fontan outcomes

Table 4 Cardiovascular magnetic resonance results for Fontan patients with and those without the composite outcome

	Composite outcomes N = 22	No composite outcome N = 33	P Value
Volumetry and flows
Mass indexed (g/m²)	79.5 (22.8)	67.0 (20.6)	0.039
Mass/volume	0.55 (0.09)	0.57 (0.11)	0.397
EDVI (mL/m²)	146.2 (50.0)	117.5 (36.2)	0.013
ESVI (mL/m²)	87.2 (37.9)	63.6 (23.8)	0.006
SVSVI (mL/m²)	58.9 (18.2)	53.9 (18.2)	0.239
SVEF (%)	41.9 (8.9)	46.4 (7.5)	0.045
APC flow (L/m²)	0.81 (0.50)	0.51 (0.38)	0.017
Feature tracking
Longitudinal strain (%)	− 12.4 (6.3)	− 15.4 (6.5)	0.299
Radial strain (%)	6.1 (1.6)	6.6 (1.3)	0.264
Circumferential strain (%)	− 21.5 (6.8)	− 25.0 (4.2)	0.029
STD-T2P	2.0 (0.9)	1.7 (0.9)	0.287
Myocardial fibrosis and scarring
ECV freewall (%)	25.1 (4.4)	28.1 (8.9)	0.098
Native T1 freewall (ms)	1063 (62)	1026 (59)	0.029
LGE prevalence (%)	2 (9%)	6 (18%)	0.153
Coupling and wall and fiber stress
VAC ratio	1.5 (0.6)	1.2 (0.4)	0.043
ESWS (kPA)	19.3 (4.1)	17.4 (3.6)	0.084
ESFS (kPA)	12.6 (1.9)	12.0 (1.7)	0.225

APC, aortopulmonary collateral; DLV, dominant left ventricle; DRV, dominant right ventricle; ECV, extracellular volume; EDVI,end diastolic volume indexed; ESFS, end systolic fiber stress; ESVI, end systolic volume indexed; ESWS, end systolic wall stress; LGE, late gadolinium enhancement; STD-T2P, standard deviation of the times to peak CS of all midventricular short axis segments; SVEF, systemic ventricle ejection fraction; SVSVI, systemic ventricle strove volume indexed; VAC, ventricular arterial coupling
Wilcoxon rank-sum test for continuous variables, and Fisher's exact test for categorical variables

ISSN: 1532-429X