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Table 3 Multivariable Cox regression analysis for predicting MACE

From: Prognostic value of resting coronary sinus flow determined by phase-contrast cine cardiovascular magnetic resonance in patients with known or suspected coronary artery disease

 

Known CAD N = 693

Suspected CAD N = 519

Multivariable model 1*

Multivariable model 2↑

Multivariable model 1*

Multivariable model 2↑

Hazard ratio (95% CI)

P-value

Hazard ratio (95% CI)

P-value

Hazard ratio (95% CI)

P-value

Hazard ratio (95% CI)

P-value

Age

1.04 (1.00–1.07)

0.022

1.03 (0.99–1.07)

0.034

1.08 (1.04–1.12)

< 0.001

1.04 (1.00–1.08)

0.023

Male

0.60 (0.25–1.44)

0.25

0.66 (0.26 –1.62)

0.36

1.72 (0.79–3.72)

0.16

2.13 (0.94–4.85)

0.068

Hypertension

0.97 (0.39–2.37)

0.94

0.87 (0.36–2.10)

0.76

1.16 (0.54–2.47)

0.69

1.15 (0.54–2.46)

0.71

Dyslipidemia

0.79 (0.34–1.89)

0.60

0.82 (0.36–1.89)

0.64

0.78 (0.38–1.61)

0.51

0.36 (0.16–0.77)

0.42

Diabetes mellitus

0.92 (0.48–1.80)

0.82

1.49 (0.81–2.73)

0.19

1.50 (0.79–2.84)

0.20

1.17 (0.62–2.23)

0.61

LVEF

0.95 (0.92–0.97)

< 0.001

0.95 (0.92–0.97)

 < 0.001

0.98 (0.96–1.00)

0.11

0.99 (0.97–1.00)

0.21

LV mass

0.99 (0.99–1.01)

0.90

0.99 (0.98–1.01)

0.70

0.98 (0.97–1.00)

0.11

0.98 (0.97–1.00)

0.026

Presence of LGE

  

1.27 (0.48–3.35)

0.62

  

1.40 (0.68–2.88)

0.35

%LGE

0.98 (0.95–1.02)

0.31

  

0.96 (0.91–1.00)

0.042

  

Ischemia > 10%

  

4.96 (2.50–9.83)

< 0.001

  

7.62 (3.69–15.7)

 < 0.001

Ischemia extent

1.06 (1.03–1.08)

 < 0.001

  

1.07 (1.04–1.09)

 < 0.001

  

Rest CSBF > median

  

3.18 (1.34–7.51)

0.0083

  

23.3 (5.19–104.9)

 < 0.001

Rest CSBF

1.01 (1.00–1.02)

 < 0.001

  

1.02 (1.01–1.02)

 < 0.001

  
  1. *Model 1 uses LGE, ischemia and CFR as continuous variables. ☨Model 2 uses LGE, ischemia and CFR as categorial variables
  2. CSBF coronary sinus blood flow, CFR coronary flow reserve, CI confidence interval, CS coronary sinus, LGE late gadolinium enhancement, LVEF left ventricular ejection fraction, MACE major adverse cardiac events