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Table 3 Multivariable Cox regression analysis for predicting MACE

From: Prognostic value of resting coronary sinus flow determined by phase-contrast cine cardiovascular magnetic resonance in patients with known or suspected coronary artery disease

  Known CAD N = 693 Suspected CAD N = 519
Multivariable model 1* Multivariable model 2↑ Multivariable model 1* Multivariable model 2↑
Hazard ratio (95% CI) P-value Hazard ratio (95% CI) P-value Hazard ratio (95% CI) P-value Hazard ratio (95% CI) P-value
Age 1.04 (1.00–1.07) 0.022 1.03 (0.99–1.07) 0.034 1.08 (1.04–1.12) < 0.001 1.04 (1.00–1.08) 0.023
Male 0.60 (0.25–1.44) 0.25 0.66 (0.26 –1.62) 0.36 1.72 (0.79–3.72) 0.16 2.13 (0.94–4.85) 0.068
Hypertension 0.97 (0.39–2.37) 0.94 0.87 (0.36–2.10) 0.76 1.16 (0.54–2.47) 0.69 1.15 (0.54–2.46) 0.71
Dyslipidemia 0.79 (0.34–1.89) 0.60 0.82 (0.36–1.89) 0.64 0.78 (0.38–1.61) 0.51 0.36 (0.16–0.77) 0.42
Diabetes mellitus 0.92 (0.48–1.80) 0.82 1.49 (0.81–2.73) 0.19 1.50 (0.79–2.84) 0.20 1.17 (0.62–2.23) 0.61
LVEF 0.95 (0.92–0.97) < 0.001 0.95 (0.92–0.97)  < 0.001 0.98 (0.96–1.00) 0.11 0.99 (0.97–1.00) 0.21
LV mass 0.99 (0.99–1.01) 0.90 0.99 (0.98–1.01) 0.70 0.98 (0.97–1.00) 0.11 0.98 (0.97–1.00) 0.026
Presence of LGE    1.27 (0.48–3.35) 0.62    1.40 (0.68–2.88) 0.35
%LGE 0.98 (0.95–1.02) 0.31    0.96 (0.91–1.00) 0.042   
Ischemia > 10%    4.96 (2.50–9.83) < 0.001    7.62 (3.69–15.7)  < 0.001
Ischemia extent 1.06 (1.03–1.08)  < 0.001    1.07 (1.04–1.09)  < 0.001   
Rest CSBF > median    3.18 (1.34–7.51) 0.0083    23.3 (5.19–104.9)  < 0.001
Rest CSBF 1.01 (1.00–1.02)  < 0.001    1.02 (1.01–1.02)  < 0.001   
  1. *Model 1 uses LGE, ischemia and CFR as continuous variables. ☨Model 2 uses LGE, ischemia and CFR as categorial variables
  2. CSBF coronary sinus blood flow, CFR coronary flow reserve, CI confidence interval, CS coronary sinus, LGE late gadolinium enhancement, LVEF left ventricular ejection fraction, MACE major adverse cardiac events