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Table 2 Univariate predictors of new onset AF in all patients

From: Incremental value of left atrial booster and reservoir strain in predicting atrial fibrillation in patients with hypertrophic cardiomyopathy: a cardiovascular magnetic resonance study

  Univariate analysis
HR (95% CI) P value prior to correction
Baseline and clinical
Age at scan, per year 1.07 (1.04–1.10)  < 0.001*
Age ≥ 55 years (rounded ROC threshold) 5.94 (2.50–14.09)  < 0.001*
Male sex 0.95 (0.43–2.11) 0.903
Systolic blood pressure, per mmHg 1.01 (0.99–1.03) 0.341
Diastolic blood pressure, per mmHg 1.03 (0.99–1.06) 0.155
Body mass index, per unit 1.03(0.96–1.12) 0.393
Hypertension 2.00 (0.99–4.03) 0.051
Diabetes 0.73(0.17–3.07) 0.669
Smoking history 1.16 (0.55–2.45) 0.692
Hypercholesterolemia 1.04 (0.36–2.96) 0.947
Family history of SCD 1st degree relative 0.45 (0.17–2.23) 0.454
Family history of SCD 2nd degree relative 1.21 (0.42–3.46) 0.725
SCD risk score (ESC) 1.04 (0.86–1.26) 0.673
VT 1.43 (0.59–3.46) 0.433
TIA stroke 2.92 (0.69–12.31) 0.145
Syncope 0.48 (0.11–2.02) 0.318
NYHA class 1.79 (1.09–2.93) 0.021
LGE, presence or absence 6.27 (0.85–46.05) 0.071
LGE mass, g 1.00 (0.98–1.02) 0.871
LGE, % 1.00 (0.96–1.04) 0.926
Presence of sarcomeric variant 0.52 (0.23–1.17) 0.113
Mitral regurgitation presence (any grade) vs absence 1.16 (0.81–1.67) 0.407
Mitral regurgitation grade 1/nomitral regurgitation vs grade 2/3/4 2.16 (0.97–4.79) 0.058
Medication
Beta-blockers 1.22 (0.61–2.44) 0.577
Calcium channel blockers 1.96 (0.95–4.02) 0.067
ACE-I/ARB 1.61 (0.78–3.34) 0.201
Diuretics 0.88 (0.12–6.46) 0.899
Aspirin 1.00 (0.48–2.09) 0.994
CMR: LA
LA diameter, mm, continuous 1.05 (0.99–1.12) 0.046
LA diameter ≥ 45 mm (ESC threshold) 1.58 (0.61–4.12) 0.348
LA diameter ≥ 42 mm (ROC threshold rounded) 2.11 (1.05–4.25) 0.036
LAEDV index, mL/m2, continuous 1.02 (1.01–1.04) 0.023
LAEDV index ≥ 50 mL/m2 (ROC threshold rounded) 2.15 (1.08–4.27) 0.029
LAESV index, mL/m2, continuous 1.04 (1.02–1.06)  < 0.001*
LAESV index ≥ 27 mL/m2 (ROC threshold rounded) 2.42 (1.22–4.82) 0.012
LA reservoir strain, % (continuous) 0.86 (0.81–0.91)  < 0.001*
LA reservoir strain ≤ 18% (ROC threshold rounded) 3.64 (1.81–7.32)  < 0.001*
LA conduit strain, %, continuous 0.88 (0.81–0.95) 0.002*
LA conduit strain ≤ 12% (ROC threshold rounded) 3.15 (1.29–7.72) 0.012
LA booster strain, %, continuous 0.87 (0.78–0.97) 0.014
LA booster strain ≤ 8% (ROC threshold rounded) 2.93 (1.44–5.95) 0.003*
LAEF (%) continuous 0.94 (0.92–0.97)  < 0.001*
LAEF ≤ 45%, (ROC threshold rounded) 3.42 (1.72–6.78)  < 0.001*
CMR: left ventricle
LV maximal wall thickness, mm 1.06 (1.00–1.14) 0.059
LV mass, grams 1.00 (1.00–1.01) 0.180
LVOT max pressure gradient, mmHg 1.04 (0.95–1.14) 0.350
LVEDV index (mL/m2) 0.98 (0.95–1.00) 0.069
LVESV index (mL/m2) 0.96 (0.91–1.01) 0.114
LV stroke volume index, mL/m2 0.98 (0.94–1.01) 0.163
LV ejection fraction, % 1.02 (0.97–1.07) 0.506
  1. LA left atria, LAEDV left atrial end diastolic volume, LAEF left atrial ejection fraction, LAESV left atrial end systolic volume, LGE late gadolinium enhancement (5-SD), LGE % percentage of tissue enhanced by gadolinium, LV left ventricle, LVOT left ventricular outflow tract, LVEDV left ventricular end diastolic volume, LVESV left ventricular end systolic volume, LVSV left ventricular stroke volume, NYHA New York Heart Association, SCD sudden cardiac death, TIA transient ischemic attack, VT ventricular tachycardia
  2. *Indicates a significant difference given Bonferroni correction to the P value as stated in the methods