Table 2 Univariate predictors of new onset AF in all patients
| Â | Univariate analysis | |
|---|---|---|
HR (95% CI) | P value prior to correction | |
Baseline and clinical | ||
Age at scan, per year | 1.07 (1.04–1.10) |  < 0.001* |
Age ≥ 55 years (rounded ROC threshold) | 5.94 (2.50–14.09) |  < 0.001* |
Male sex | 0.95 (0.43–2.11) | 0.903 |
Systolic blood pressure, per mmHg | 1.01 (0.99–1.03) | 0.341 |
Diastolic blood pressure, per mmHg | 1.03 (0.99–1.06) | 0.155 |
Body mass index, per unit | 1.03(0.96–1.12) | 0.393 |
Hypertension | 2.00 (0.99–4.03) | 0.051 |
Diabetes | 0.73(0.17–3.07) | 0.669 |
Smoking history | 1.16 (0.55–2.45) | 0.692 |
Hypercholesterolemia | 1.04 (0.36–2.96) | 0.947 |
Family history of SCD 1st degree relative | 0.45 (0.17–2.23) | 0.454 |
Family history of SCD 2nd degree relative | 1.21 (0.42–3.46) | 0.725 |
SCD risk score (ESC) | 1.04 (0.86–1.26) | 0.673 |
VT | 1.43 (0.59–3.46) | 0.433 |
TIA stroke | 2.92 (0.69–12.31) | 0.145 |
Syncope | 0.48 (0.11–2.02) | 0.318 |
NYHA class | 1.79 (1.09–2.93) | 0.021 |
LGE, presence or absence | 6.27 (0.85–46.05) | 0.071 |
LGE mass, g | 1.00 (0.98–1.02) | 0.871 |
LGE, % | 1.00 (0.96–1.04) | 0.926 |
Presence of sarcomeric variant | 0.52 (0.23–1.17) | 0.113 |
Mitral regurgitation presence (any grade) vs absence | 1.16 (0.81–1.67) | 0.407 |
Mitral regurgitation grade 1/nomitral regurgitation vs grade 2/3/4 | 2.16 (0.97–4.79) | 0.058 |
Medication | ||
Beta-blockers | 1.22 (0.61–2.44) | 0.577 |
Calcium channel blockers | 1.96 (0.95–4.02) | 0.067 |
ACE-I/ARB | 1.61 (0.78–3.34) | 0.201 |
Diuretics | 0.88 (0.12–6.46) | 0.899 |
Aspirin | 1.00 (0.48–2.09) | 0.994 |
CMR: LA | ||
LA diameter, mm, continuous | 1.05 (0.99–1.12) | 0.046 |
LA diameter ≥ 45 mm (ESC threshold) | 1.58 (0.61–4.12) | 0.348 |
LA diameter ≥ 42 mm (ROC threshold rounded) | 2.11 (1.05–4.25) | 0.036 |
LAEDV index, mL/m2, continuous | 1.02 (1.01–1.04) | 0.023 |
LAEDV index ≥ 50 mL/m2 (ROC threshold rounded) | 2.15 (1.08–4.27) | 0.029 |
LAESV index, mL/m2, continuous | 1.04 (1.02–1.06) |  < 0.001* |
LAESV index ≥ 27 mL/m2 (ROC threshold rounded) | 2.42 (1.22–4.82) | 0.012 |
LA reservoir strain, % (continuous) | 0.86 (0.81–0.91) |  < 0.001* |
LA reservoir strain ≤ 18% (ROC threshold rounded) | 3.64 (1.81–7.32) |  < 0.001* |
LA conduit strain, %, continuous | 0.88 (0.81–0.95) | 0.002* |
LA conduit strain ≤ 12% (ROC threshold rounded) | 3.15 (1.29–7.72) | 0.012 |
LA booster strain, %, continuous | 0.87 (0.78–0.97) | 0.014 |
LA booster strain ≤ 8% (ROC threshold rounded) | 2.93 (1.44–5.95) | 0.003* |
LAEF (%) continuous | 0.94 (0.92–0.97) |  < 0.001* |
LAEF ≤ 45%, (ROC threshold rounded) | 3.42 (1.72–6.78) |  < 0.001* |
CMR: left ventricle | ||
LV maximal wall thickness, mm | 1.06 (1.00–1.14) | 0.059 |
LV mass, grams | 1.00 (1.00–1.01) | 0.180 |
LVOT max pressure gradient, mmHg | 1.04 (0.95–1.14) | 0.350 |
LVEDV index (mL/m2) | 0.98 (0.95–1.00) | 0.069 |
LVESV index (mL/m2) | 0.96 (0.91–1.01) | 0.114 |
LV stroke volume index, mL/m2 | 0.98 (0.94–1.01) | 0.163 |
LV ejection fraction, % | 1.02 (0.97–1.07) | 0.506 |