Reduced exercise capacity in patients with systemic sclerosis is associated with lower peak tissue oxygen extraction: a cardiovascular magnetic resonance-augmented cardiopulmonary exercise study

Table 2 Hemodynamic measurements for pulmonary hypertension groups, clinical measurements for all patient groups

	SSc	SSc-PAH	NC-PAH	p value
Hemoglobin (g/L)	121.9 ± 11.4	123.5 ± 14.2	133.3 ± 22.2	0.14
FEV1 (%predicted)	95.5 ± 17.5	85.5 ± 13.2	88.9 ± 14.7	0.20
FVC (%predicted)	98.0 ± 19.8	91.8 ± 15.6	98.1 ± 18.3	0.56
DLCO (%predicted)	67.4 ± 14.7	39.4 ± 14.1^‡§	64.3 ± 16.9	< 0.001
PVR* (dynes/s/cm⁻⁵)	–	346 (146–1373)	444 (180–1358)	0.17
mPAP* (mmHg)	–	32 (20–80)	39 (25–64)	0.17
6MWT (m)	–	372 ± 105	451 ± 94	0.042

PVR pulmonary vascular resistance, mPAP mean pulmonary arterial pressure, 6MWT 6-minute walk test, FEV1 forced expiratory volume in 1 s, FVC forced vital capacity, DLCO diffusion capacity of the lung for carbon monoxide. Normally distributed data displayed as mean ± SD. *Denotes non-normally distributed data shown as median (range). ^‡Significant difference between SSc and SSc-PAH groups. ^§Significant difference between NC-PAH and the indicated SSc groups

ISSN: 1532-429X