Table 2 CMR parameters and annualized change by composite outcome status

Follow-up time, years,

Median (IQR)

10.2 (6.1,14.5)

6.2 (3.9, 8.4)

10.8 (6.9, 15.3)

< 0.001

Male

100 (64.1%)

14 (63.6%)

86 (64.2%)

0.96

Ventricular dominance

0.03

 Left ventricle 

83 (53.2%)

7 (31.8%)

76 (56.7%)

 Right ventricle 

73 (46.8%)

15 (68.2%)

58 (43.3%)

At the first CMR

 Age at CMR, years

17.8 ± 9.6

22.0 ± 13.5

17.1 ± 8.6

0.11

 BSA, m²

1.47 ± 0.41

1.57 ± 0.53

1.46 ± 0.39

0.34

 EDVI, ml/BSA^1.3

98.3 ± 37.5

120.9 ± 58.3

94.6 ± 31.7

0.05

 ESVI, ml/BSA^1.3

47.7 ± 26.8

63.9 ± 43.8

45.0 ± 22.0

0.06

 Mass index, g/BSA^1.3

62.0 ± 23.1

80.6 ± 32.5

58.8 ± 19.6

0.005

 EF, %

53.3 ± 10.0

49.5 ± 12.4

54.0 ± 9.5

0.05

 Mass-to-volume ratio

0.69 ± 0.31

0.79 ± 0.43

0.67 ± 0.29

0.23

 ESWS, kPa

17.7 ± 6.7

20.5 ± 7.5

17.4 ± 6.6

0.17

At the last CMR

n = 155^b

n = 21

n = 134

 Age at CMR, years

23.7 ± 10.6

26.7 ± 14.5

23.3 ± 9.9

0.30

 Time between 2 CMRs, Median (IQR)

5.0 (2.3, 8.7)

4.4 (2.0, 5.9)

5.1 (2.3, 9.0)

0.04

 BSA, m²

1.69 ± 0.37

1.72 ± 0.46

1.68 ± 0.36

0.71

 EDVI, ml/BSA^1.3

106.3 ± 39.5

146.3 ± 69.9

100.0 ± 28.0

0.007

 ESVI, ml/BSA^1.3

54.8 ± 34.5

88.7 ± 68.3

49.5 ± 21.6

0.02

 Mass indx, g/BSA^1.3

54.2 ± 18.0

73.5 ± 26.5

51.2 ± 14.2

0.001

 EF, %

50.9 ± 9.9

43.8 ± 13.8

52.0 ± 8.7

0.01

 Mass-to-volume ratio

0.54 ± 0.16

0.56 ± 0.24

0.53 ± 0.14

0.58

 ESWS, kPa

18.8 ± 7.8

22.4 ± 10.9

18.3 ± 7.1

0.11

Annual change in CMR (last-first)/(years between last and first)

 EDVI, ml/BSA^1.3/year,

Median (IQR)

0.93 (− 0.97, 3.20)^a

4.68 (1.11, 8.79)^a

0.70 (− 1.40, 2.64)^a

0.003

 ESVI, ml/BSA^1.3/year,

Median (IQR)

0.84 (− 0.72, 2.51)^a

3.62 (0.91, 9.60)^a

0.70 (− 0.76, 1.99)^a

< 0.001

 Mass index, g/BSA^1.3/year,

Median (IQR)

− 1.06 (− 3.12, 0.71)^a

− 4.49 (− 5.30, 0.36)

− 0.92 (− 2.21, 0.71)^a

0.04

 EF, %/year,

Median (IQR)

− 0.35 (− 1.25, 0.41)^a

− 0.99 (− 5.12, 0.29)^a

− 0.30 (− 1.17, 0.41)^a

0.03

 Mass-to-volume ratio, /year,

Median (IQR)

− 0.02 (− 0.05, 0.01)^a

− 0.06 (− 0.10, − 0.03)^a

− 0.01 (− 0.04, 0.01)^a

0.006

 ESWS, kPa/year,

Median (IQR)

0.30 (− 0.59, 1.23)

3.12 (1.55, 4.97)^a

0.17 (− 0.73, 0.81)

0.002