Association of left ventricular abnormalities with incident cerebrovascular events and sources of thromboembolism in patients with chronic Chagas cardiomyopathy

Table 5 Multivariable Cox proportional hazard models for the primary combined outcome (stroke, TIA, atrial fibrillation, atrial flutter, and intracavitary thrombus) in patients with chronic Chagas cardiomyopathy

	Multivariable analysis
	HR	95% CI	p-value
Model 1
Age (years)	1.02	0.99–1.06	0.144
LV mass index (g/m²)	1.00	0.98–1.02	0.373
LVEF (%)	0.96	0.93–0.99	0.014
LV LGE mass (g)	1.14	0.74–1.74	0.248
LV aneurysm (presence vs. absence)	1.74	0.71–4.23	0.221
Model 2
Age (years)	1.02	0.99–1.06	0.089
LV mass index (g/m²)	1.01	0.99–1.02	0.215
LVEF < 40%	3.16	1.38–7.25	0.006
LV LGE (presence vs. absence)	2.46	0.66–9.18	0.179
LV aneurysm (presence vs. absence)	1.74	0.91–4.33	0.221

Model 1: Left ventricular ejection fraction and late gadolinium enhancement assessed as continuous variables
Model 2: Left ventricular ejection fraction and late gadolinium enhancement assessed as categorical variables
CI confidence interval, LVEF left ventricular ejection fraction, HR hazard ratio, LGE late gadolinium enhancement, LV left ventricular

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