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Table 1 Baseline clinical and cardiovascular magnetic resonance (CMR) characteristics of stage 3 chronic kidney disease (CKD) patients with or without inducible ischemia (N = 702)

From: Safety and incremental prognostic value of stress cardiovascular magnetic resonance in patients with known chronic kidney disease

 

All patients

(N = 702)

Without ischemia

(N = 557)

With ischemia

(N = 145)

p value

Demographics

    

 Age, years

71.4 ± 8.8

71.3 ± 8.8

71.7 ± 8.8

0.64

 Male, n (%)

492 (70.1)

392 (70.4)

100 (69.0)

0.46

 BMI, kg/m2

26.8 ± 3.2

27.0 ± 3.3

26.0 ± 2.6

 < 0.001

Cardiovascular risk factors, n (%)

    

 Diabetes mellitus

347 (49.4)

255 (45.8)

92 (63.5)

 < 0.001

 Hypertension

525 (74.8)

413 (74.1)

112 (77.2)

0.51

 Dyslipidemia

411 (58.5)

326 (58.5)

85 (58.6)

1.00

 Current or previous smoking

107 (15.2)

86 (15.4)

21 (14.5)

0.88

 Family history of CAD

54 (7.7)

51 (9.2)

3 (2.1)

0.007

 Obesity (BMI ≥ 30 kg/m2)

84 (12.0)

80 (14.4)

4 (2.8)

 < 0.001

 Time between CKD diagnosis and CMR, years

3.6 ± 2.9

3.2 ± 2.8

5.4 ± 3.1

 < 0.001

 eGFR, ml/min/1.73 m2

41 ± 9

43 ± 9

36 ± 10

 < 0.001

 Ten-year risk for fatal CAD (%)*

3.6 (1.0–5.9)

3.5 (0.9–5.8)

4.2 (1.2–6.3)

 < 0.001

Indications to stress CMR, n (%)

    

 Symptomatic angina

618 (88.0)

513 (92.1)

105 (72.4)

 < 0.001

 Dyspnea

88 (12.0)

44 (7.9)

44 (30.3)

 < 0.001

Stress CMR findings

    

 LV ejection fraction, %

62.8 ± 9.8

62.8 ± 9.1

62.8 ± 12.1

0.97

 LV end-diastolic volume index, ml/m2

62.8 ± 13.4

62.5 ± 12.9

63.9 ± 16.2

0.34

 LV end-systolic volume index, ml/m2

22.9 ± 4.9

23.0 ± 4.9

22.4 ± 4.7

0.20

 LV mass, g/m2

89 ± 12

89 ± 11

90 ± 12

0.41

 RV dysfunction†

14 (1.9)

10 (1.8)

4 (2.8)

0.13

 Presence of unrecognized MI, n (%)

112 (16.0)

77 (13.8)

35 (24.1)

0.004

 Number of segments of LGE

0.4 ± 1.1

0.3 ± 0.8

0.9 ± 1.8

 < 0.001

 Number of segments of ischemia

0.5 ± 1.3

0.0 ± 0.0

2.4 ± 1.7

 < 0.001

 RPP at baseline, mmHg/beats/min

9.1 (7.0–11.5)

9.0 (6.8–11.4)

9.3 (7.1–11.7)

0.65

 RPP at stress, mmHg/beats/min

10.8 (8.4–13.0)

10.8 (8.6–12.9)

11.0 (9.2–13.6)

0.70

Recruitment center, n (%)

    

 Institut cardiovasculaire Paris Sud

513 (73.1)

394 (70.7)

119 (82.1)

 < 0.001

 Lariboisiere University Hospital

189 (26.9)

163 (29.3)

26 (17.9)

 < 0.001

  1. Values are n (%), mean ± SD, or median (interquartile range)
  2. BMI body mass index; CMR cardiovascular magnetic resonance; eGFR estimated glomerular filtration rate; LGE late gadolinium enhancement; LV left ventricle; MI Myocardial infarction; RPP rate-pressure product (pressure mmHg × heart rate bpm)/1000; SD: standard deviation; RV right ventricle
  3. *Based on a modified SCORE project (https://www.escardio.org/Education/Practice-Tools/CVD-prevention-toolbox/SCORE-Risk-Charts) that did not take into account the total cholesterol level
  4. †Defined by right ventricle ejection fraction < 45%
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Journal of Cardiovascular Magnetic Resonance

ISSN: 1532-429X

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