Safety and incremental prognostic value of stress cardiovascular magnetic resonance in patients with known chronic kidney disease

Table 5 Univariable and multivariable competing risk regression analysis (N = 702)

	Nonfatal MI				Cardiovascular mortality
	Univariable analysis		Multivariable analysis^†		Univariable analysis		Multivariable analysis^†
	sHR* (95% CI)	p value	sHR* (95% CI)	p value	sHR* (95% CI)	p value	sHR* (95% CI)	p value
Age	0.97 (0.95–0.99)	0.009	1.08 (1.03–1.13)	0.002	1.08 (1.03;1.12)	< 0.001	1.09 (1.03–1.15)	< 0.001
Male	3.64 (1.11–11.9)	0.033	1.02 (0.99–1.06)	0.23	0.66 (0.36–1.21)	0.18	-	-
BMI	1.10 (1.05–1.16)	< 0.001	1.16 (1.06–1.27)	0.001	0.97 (0.89–1.07)	0.55	-	-
Diabetes mellitus	3.73 (1.61–8.62)	0.002	4.61 (1.89–11.2)	< 0.001	4.69 (2.19: 10.00)	< 0.001	5.30 (1.78–11.3)	< 0.001
Hypertension	0.99 (0.45–2.19)	0.98	-	-	1.93 (0.87–4.27)	0.11	1.99 (0.85–4.43)	0.72
Dyslipidemia	0.83 (0.40–1.74)	0.64	-	-	0.57 (0.32–1.01)	0.055	-	-
Current or previous smoking	2.55 (1.20–5.43)	0.015	2.30 (0.87–7.26)	0.41	0.99 (0.44–2.22)	0.98	-	-
LVEF	0.96 (0.93–0.99)	0.002	0.97 (0.92–1.06)	0.57	1.02 (0.99–1.06)	0.23	-	-
eGFR	0.80 (0.59–0.95)	0.02	0.87 (0.71–1.04)	0.41	0.70 (0.50–0.87)	0.003	0.78 (0.62–0.98)	0.04
Time between CKD diagnosis and CMR exam	1.01 (0.97–1.05)	0.58	-	-	1.89 (0.87–4.23)	0.45	-	-
Presence of inducible ischemia	17.0 (7.09–41.0)	< 0.001	8.21 (4.22–15.9)	< 0.001	8.49 (4.53–15.9)	< 0.001	7.35 (4.02–13.9)	< 0.001
Presence of unrecognized MI	4.08 (1.98–8.42)	< 0.001	5.31 (2.75–10.2)	< 0.001	3.79 (2.10–6.82)	< 0.001	6.02 (2.97–11.9)	< 0.001

*HR of the subdistribution hazard function
^†Covariates by stepwise variable selection with entry and exit criteria set at the p < 0.20 level: for nonfatal MI: age, male, body mass index, diabetes mellitus, smoking, LVEF, eGFR, presence of unrecognized MI, and presence of ischemia; for CV mortality: age, diabetes mellitus, hypertension, eGFR, presence of unrecognized MI, and presence of ischemia
Same as in Table 2. HR hazard ratio

ISSN: 1532-429X