Cardiac reverse remodeling in primary mitral regurgitation: mitral valve replacement vs. mitral valve repair

Craven, Thomas P.; Chew, Pei G.; Dobson, Laura E.; Gorecka, Miroslawa; Parent, Martine; Brown, Louise A. E.; Saunderson, Christopher E. D.; Das, Arka; Chowdhary, Amrit; Jex, Nicholas; Higgins, David M.; Dall’Armellina, Erica; Levelt, Eylem; Schlosshan, Dominik; Swoboda, Peter P.; Plein, Sven; Greenwood, John P.

doi:10.1186/s12968-023-00946-9

Journal of Cardiovascular Magnetic Resonance

Table 6 Univariate and multivariate baseline predictors of post-surgical indexed LVEDV, LVEF and MR-volume at follow-up

From: Cardiac reverse remodeling in primary mitral regurgitation: mitral valve replacement vs. mitral valve repair

Baseline parameters	Univariate				Multivariate
Baseline parameters	B ± Std Error	ß	95% CI	p	B ± Std Error	ß	95% CI	p
Left ventricular end-diastolic volume (indexed) at follow up
CABG	− 23.503 ± 13.704	− 0.236	− 51.028 to 4.022	0.093				NS
AF	− 22.291 ± 6.877	− 0.417	− 36.105 to − 8.477	0.002				NS
NYHA class	− 12.776 ± 4.909	− 0.345	− 22.637 to − 2.915	0.012	− 8.167 ± 3.879	− 0.222	− 16.000 to − 0.333	0.041
Heart rate	− 0.687 ± 0.244	− 0.370	− 1.178 to − 0.197	0.007				NS
6MWT (m)	0.090 ± 0.040	0.300	0.009 ± 0.171	0.030				NS
LVEDV (ml/m²)	0.637 ± 0.091	0.703	0.454 ± 0.820	< 0.001	0.934 ± 0.162	1.011	0.605 to 1.262	< 0.001
LVESV (ml/m²)	0.844 ± 0.144	0.637	0.554 ± 1.134	< 0.001				NS
LVSV (ml/m²)	0.898 ± 0.211	0.515	0.474 ± 1.322	< 0.001				NS
LVEF (%)	− 0.984 ± 0.453	− 0.284	− 1.857 ± − 0.039	0.041				NS
LVM (g/m²)	0.909 ± 0.200	0.540	0.507 ± 1.312	< 0.001				NS
RVEDV (ml/m²)	0.705 ± 0.168	0.507	0.365 ± 1.046	< 0.001				NS
RVESV (ml/m²)	0.633 ± 0.234	0.357	0.163 ± 1.103	0.009				NS
RVSV (ml/m²)	1.134 ± 0.337	0.430	0.458 ± 1.810	0.001				NS
ECV(%)	2.830 ± 1.147	0.352	0.518 ± 5.142	0.018				NS
MR-Rvol (ml/m²)	0.798 ± 0.276	0.379	0.244 ± 1.352	0.006	− 0.995 ± 0.364	− 0.481	− 1.729 to − 0.260	0.009
AR-Rvol (ml/m²)	6.474 ± 3.588	0.247	− 0.731 ± 13.680	0.077				NS
Left ventricular ejection fraction at follow-up
LVEDV (ml/m²)	− 0.153 ± 0.036	− 0.513	− 0.226 to − 0.080	< 0.001				NS
LVESV (ml/m²)	− 0.253 ± 0.050	− 0.579	− 0.354 to − 0.152	< 0.001	− 0.253 ± 0.050	− 0.579	− 0.354 to − 0.152	< 0.001
LVEF (%)	0.473 ± 0.141	0.430	0.191 to 0.755	0.001				NS
EF-LVEF (%)	0.421 ± 0.131	0.415	0.159 to 0.684	0.002				NS
LVM (g/m²)	− 0.231 ± 0.071	− 0.415	− 0.374 to − 0.087	0.002				NS
RVEDV (ml/m²)	− 0.125 ± 0.062	− 0.272	− 0.250 to 0.001	0.051				NS
RVESV (ml/m²)	− 0.139 ± 0.080	− 0.238	− 0.300 to 0.022	0.089				NS
MR-Rvol (ml/m²)	− 0.222 ± 0.093	− 0.320	− 0.409 to − 0.035	0.021				NS
AR-Rvol (ml/m²)	− 2.461 ± 1.171	− 0.285	− 4.813 to − 0.110	0.041				NS
TR-Rvol (ml/m²)	− 0.284 ± 0.156	− 0.250	− 0.597 to 0.029	0.074				NS
Mitral regurgitant volume (indexed) at follow-up
MVR	− 4.511 ± 1.470	− 0.398	− 7.463 to − 1.559	0.003	− 4.861 ± 1.278	− 0.429	− 7.432 to − 2.291	< 0.001
Male	4.404 ± 1.773	0.332	0.844 to 7.965	0.016				NS
Heart rate	− 0.096 ± 0.054	− 0.246	− 0.204 to 0.011	0.079				NS
LVEDV (ml/m²)	0.075 ± 0.025	0.394	0.025 to 0.125	0.004				NS
LVESV (ml/m²)	0.079 ± 0.038	0.284	0.003 to 0.155	0.041				NS
LVSV (ml/m²)	0.142 ± 0.048	0.386	0.045 to 0.238	0.005	0.103 ± − 0.048	0.279	0.007 to 0.199	0.037
LVM (g/m²)	0.144 ± 0.046	0.406	0.052 to 0.236	0.003	0.100 ± 0.046	0.281	0.007 to 0.192	0.036
RVEDV (ml/m²)	0.078 ± 0.040	0.266	− 0.002 to 0.158	0.056				NS
RVESV (ml/m²)	0.095 ± 0.051	0.255	− 0.007 to 0.198	0.068				NS
MR-Rvol (ml/m²)	0.170 ± 0.058	0.383	0.053 to 0.286	0.005				NS

All baseline variables with univariate p < 0.1 presented and utilized in multivariate analysis. All volumetric indices indexed to body surface area for accurate comparison. 6MWT: 6-min walk test distance; AR: aortic regurgitation; CABG: coronary artery bypass grafting; ECV: extracellular volume fraction; EDV: end-diastolic volume; EF-LVEF: effective forward left ventricular ejection fraction; ESV: end-systolic volume; i: indexed to body surface area; LA: left atrial; LV: left ventricular; LVEF: left ventricular ejection fraction; LVM: left ventricular mass; MR: mitral regurgitation; MVR: mitral valve replacement; Rvol: regurgitant volume; NYHA: New York Heart Association; RV: right ventricular; SV: stroke volume; TR: tricuspid regurgitation

Back to article page

ISSN: 1532-429X

Contact us

Submission enquiries: Access here and click Contact Us
General enquiries: info@biomedcentral.com