Fig. 2
From: Modeling of factors affecting late gadolinium enhancement kinetics in MRI of cardiac amyloid
Schematic diagram of 3-compartment model of contrast agent kinetics. Dose, D, of contrast agent is injected into plasma space, with volume Vp, at initial time = 0. Contrast agent exchanges between plasma and body extravascular extracellular space (EES), with volume Ve, at a rate dependent on the permeability coefficient of the capillaries between them, K. Contrast agent also exchanges between plasma and myocardial EES, with fractional volume ve, at a rate dependent on the permeability-surface area product of the capillaries between them, PS. Contrast agent is cleared from the plasma by the kidneys, at a rate dependent on the glomerular filtration coefficient, GFR