Predictive value of cardiac magnetic resonance right ventricular longitudinal strain in patients with suspected myocarditis

Table 1 Patient characteristics

	Overall	RV GLS abnormal	RV GLS normal	p value
		(> − 15.4%)	(≤ − 15.4%)
	N = 659	N = 144	N = 515
Demographical data
Gender (male) n (%)	414 (62.8)	102 (70.8)	312 (60.6)	0.024
Age [years] mean ± SD	48.1 ± 16.1	49.5 ± 15.4	47.7 ± 16.3	0.240
BMI [kg/m²] mean ± SD	27.4 ± 5.9	28.4 ± 6.6	27.2 ± 5.7	0.024
BSA [m²] mean ± SD	2.0 ± 0.3	2.0 ± 0.3	2.0 ± 0.3	0.319
Myocarditis symptoms n (%)
Chest pain	248 (37.8)	25 (17.4)	223 (43.3)	< 0.001
Arrhythmia^a	124 (18.8)	25 (17.4)	99 (19.2)	0.613
Dyspnea NYHA II, III or IV	297 (45.1)	95 (67.4)	202 (39.2)	< 0.001
Time symptom onset to CMR [days] median (IQR)^c	10 (4–28)	14 (7–28)	8 (4–28)	0.038
Biomarkers
Troponin T [ng/l] median (IQR)	19 (1–115)	5 (1–28)	29 (1–198)	< 0.001
Above cutoff^b n (% of available^c)	186 (55)	28 (37.8)	158 (59.8)	0.001
Creatine kinase [U/l] median (IQR)	180 (80–505)	135 (56–416)	198 (89–523)	0.072
Above cutoff^b n (% of available^c)	159 (56.4)	27 (44.3)	132 (59.7)	0.031
ECG n (% of available^c)
Left bundle branch block	55 (9.2)	22 (16.9)	33 (7.1)	0.001
Right bundle branch block	37 (5.6)	7 (5.4)	30 (6.4)	0.673
ST-segment elevation	57 (8.6)	6 (4.6)	51 (10.9)	0.029

BMI: body-mass-index; BSA: body surface area; CMR: cardiovascular magnetic resonance; ECG: electrocardiogram; IQR: interquartile range; NYHA: New York Heart Association; RV GLS: right ventricular global longitudinal strain; SD: standard deviation
^aArrhythmia comprised ECG-documented sustained and non-sustained ventricular tachycardia
^bCutoff values for elevated troponin T and creatine kinase were time- and site-specific according to the essay used for analysis, and > 190U/l, respectively
^cDate of symptom onset was available in 393 (59.6%) patients, troponin T was available in 338 (51.3%) patients, and creatine kinase in 282 (42.8%) patients. ECG was available in 598 (90.7%) patients

ISSN: 1532-429X