Table 3 Cox Regression models for the combined endpoint of major adverse cardiovascular events (MACE)
MACE | Univariable analyses | Multivariable model 1a Imaging parameter without RV GLS | Multivariable model 1b Imaging parameter with additional RV GLS | Multivariable model 1c Imaging parameter with RV GLS instead of LV GLS | ||||
|---|---|---|---|---|---|---|---|---|
HR (95% CI) | p value | HRadjusted (95% CI) | p value | HRadjusted (95% CI) | p value | HRadjusted (95% CI) | p value | |
Clinical characteristics | ||||||||
Age [years] | 1.01 (1.00–1.03) | 0.022 | ||||||
Gender [male] | 0.65 (0.45–0.94) | 0.023 | ||||||
Troponin T peaka [ng/l] | 0.99 (0.99–1.00) | 0.206 | ||||||
NT-proBNPa [log pg/ml] | 2.45 (1.54–3.90) | < 0.001 | ||||||
CMR LGE | ||||||||
LV LGE present | 1.61 (1.08–2.32) | 0.024 | ||||||
LV LGE involves insertion points | 1.22 (0.77–1.94) | 0.390 | ||||||
LV LGE extent FWHM [g] | 1.04 (1.02–1.06) | < 0.001 | 1.03 (1.01–1.05) | 0.005 | 1.03 (1.01–1.05) | 0.005 | 1.03 (1.01–1.05) | 0.005 |
RV LGE presenta | 1.86 (1.07–3.24) | 0.027 | ||||||
CMR ejection fraction | ||||||||
LV EF [%] | 0.96 (0.95–0.98) | < 0.001 | 1.00 (0.98–1.03) | 0.726 | 1.00 (0.98–1.03) | 0.728 | 0.98 (0.96–1.00) | 0.074 |
RV EF [%] | 0.95 (0.94–0.97) | < 0.001 | 0.98 (0.96–0.99) | 0.038 | 0.98 (0.96–1.00) | 0.072 | 0.98 (0.96–1.00) | 0.082 |
CMR feature tracking | ||||||||
LV GLS [%] | 1.15 (1.10–1.20) | < 0.001 | 1.10 (1.01–1.20) | 0.037 | 1.10 (1.01–1.21) | 0.044 | ||
LV GCS [%] | 1.12 (1.08–1.16) | < 0.001 | ||||||
LV GRS [%] | 0.94 (0.92–0.96) | < 0.001 | ||||||
RV GLS [%] | 1.07 (1.04–1.10) | < 0.001 | 1.00 (0.96–1.04) | 0.932 | 1.01 (0.97–1.05) | 0.622 | ||
Model Chi-Square | 41.97 | 51.65 | 47.6 | |||||
Df | 4 | 5 | 4 | |||||
p value | < 0.001 | < 0.001 | < 0.001 | |||||
− 2 Log-Likelihood | 1074.4 | 1074.4 | 1179.5 | |||||
p-value vs. model without RV GLS | 0.932 | 0.623 | ||||||