Table 4 Cox Regression models for the secondary endpoint of heart failure hospitalizations
Heart failure hospitalizations | Univariable analyses | Multivariable model 2a Imaging parameter without RV GLS | Multivariable model 2b Imaging parameter with additional RV GLS | Multivariable model 2c Imaging parameter with RV GLS instead LV GLS | ||||
|---|---|---|---|---|---|---|---|---|
HR (95% CI) | p value | HRadjusted (95% CI) | p value | HRadjusted (95% CI) | p value | HRadjusted (95% CI) | p value | |
Clinical characteristics | ||||||||
Age [years] | 1.01 (0.99–1.03) | 0.145 | ||||||
Gender [male] | 0.46 (0.26–0.83) | 0.010 | ||||||
Troponin T peaka [ng/l] | 1.00 (0.99–1.00) | 0.356 | ||||||
NT-proBNPa [log pg/ml] | 3.45 (1.70–6.90) | < 0.001 | ||||||
CMR LGE | ||||||||
LV LGE present | 1.36 (0.71–2.60) | 0.350 | ||||||
LV LGE involves insertion points | 0.75 (1.32–1.79) | 0.525 | ||||||
LV LGE extent FWHM [g] | 1.05 (1.02–1.08) | 0.003 | 1.03 (1.00–1.06) | 0.061 | 1.03 (1.00–1.06) | 0.064 | 1.03 (1.00–1.06) | 0.063 |
RV LGE presenta | 2.33 (0.96–5.67) | 0.062 | ||||||
CMR ejection fraction | ||||||||
LV EF [%] | 0.93 (0.91–0.95) | < 0.001 | 1.00 (0.95–1.05) | 0.962 | 1.00 (0.95–1.05) | 0.943 | 0.96 (0.93–0.99) | 0.012 |
RV EF [%] | 0.91 (0.89–0.93) | < 0.001 | 0.96 (0.93–0.99) | 0.038 | 0.97 (0.93–1.01) | 0.179 | 0.97 (0.94–1.02) | 0.226 |
CMR feature tracking | ||||||||
LV GLS [%] | 1.38 (1.28–1.50) | < 0.001 | 1.26 (1.07–1.48) | 0.007 | 1.22 (1.02–1.44) | 0.025 | ||
LV GCS [%] | 1.30 (1.21–1.39) | < 0.001 | ||||||
LV GRS [%] | 0.85 (0.81–0.89) | < 0.001 | ||||||
RV GLS [%] | 1.17 (1.12–1.23) | < 0.001 | 1.05 (0.98–1.13) | 0.195 | 1.07 (1.01–1.15) | 0.048 | ||
Model Chi-Square | 62.5 | 85.2 | 80.8 | |||||
Df | 4 | 5 | 4 | |||||
p value | < 0.001 | < 0.001 | < 0.001 | |||||
−2 Log-Likelihood | 313.0 | 311.3 | 316.8 | |||||
p-value vs. model without RV GLS | 0.194 | 0.048 | ||||||