Fig. 4

Quantification using AUC ratios and pharmacokinetic modeling in the same healthy volunteer subjects as Fig. 3 (subjects HV6, left, and HV7, right). k_PL is the ¹³C-pyruvate to ¹³C-lactate rate and k_PB is the ¹³C-pyruvate to ¹³C-bicarbonate rate. Note the maps are only computed in regions that meet a minimum pyruvate AUC SNR threshold as pyruvate signal is required for these quantifications