Table 1 Characteristics of patients with eosinophilic myocarditis with and without cardiac magnetic resonance (CMR) imaging at presentation
From: Cardiac magnetic resonance in histologically proven eosinophilic myocarditis
All patients n = 27 | CMR+ n = 15 | CMR− n = 12 | p-value | |
|---|---|---|---|---|
Age, y | 52.0 ± 17.2 | 51.2 ± 16.8 | 53.1 ± 18.4 | 0.787 |
Sex, female, n (%) | 11 (41) | 6 (40) | 5 (42) | 1.000 |
Time from symptom onset to hospital admission, days | 3 (1–5) | 2 (1–8) | 4 (2–5) | 0.980 |
Etiology, n (%) | 0.543 | |||
Hypersensitivity | 10 (37) | 4 (27) | 6 (50) | |
Hypereosinophilic syndrome | 7 (26) | 4 (27) | 3 (25) | |
Eosinophilic granulomatosis with polyangitis | 3 (11) | 2 (13) | 1 (8) | |
Cancer | 1 (4) | 0 | 1 (8) | |
Infectiona | 1 (4) | 1 (7) | 0 | |
Undefined | 5 (19) | 4 (27) | 1 (8) | |
Key laboratory findings on admission | ||||
Peripheral eosinophilia (> 0.44 × 109/L), n (%) | 16 (59) | 9 (60) | 7 (58) | 1.000 |
Elevated cardiac troponins, n (%)b | 27 (100) | 15 (100) | 12 (100) | NA |
Elevated natriuretic peptides, n (%)c | 13/16 (81) | 9/11 (82) | 4/5 (80) | 1.000 |
Electrocardiography | ||||
ST segment elevation or depression, n (%) | 12 (44) | 7 (47) | 5 (42) | 0.795 |
T wave inversions only, n (%) | 5 (19) | 3 (20) | 2 (17) | 1.000 |
Bundle branch block, n (%) | 3 (11) | 1 (7) | 2 (17) | 0.569 |
Atrio-ventricular block, 3rd degree, n (%) | 4 (15) | 3 (20) | 1 (8) | 0.605 |
Echocardiography | ||||
Left ventricular end diastolic diameter, mm, n = 25/14/11 | 53 ± 10 | 50 ± 7 | 58 ± 12 | 0.088 |
Interventricular septal thickness, mm, n = 15/10/5 | 11 (11–15) | 12 (11–15) | 11 (10–12) | 0.286 |
Left ventricular ejection fraction, % | 41.3 ± 17.5 | 48.8 ± 17.0 | 31.9 ± 13.5 | 0.008 |
<50%, n (%) | 15 (56) | 5 (33) | 10 (83) | 0.009 |
<30%, n (%) | 8 (30) | 1 (7) | 7 (58) | 0.008 |