- Meeting abstract
- Open Access
1013 Impaired left ventricular function at rest and stress in patients with severe coronary artery disease after heart transplantation detected by dobutamine stress magnetic resonance imaging
© Merten et al; licensee BioMed Central Ltd. 2008
- Published: 22 October 2008
- Cardiac Magnetic Resonance
- Dobutamine Stress
- Impaired Left Ventricular Function
- Lower Left Ventricular Ejection Fraction
- Significant Coronary Artery Stenosis
Transplant coronary artery disease (TCAD) importantly affects long-term survival in patients after heart transplantation (HTX). Usually annual coronary angiography is used to assess presence and severity of TCAD.
We sought to use rest and dobutamine stress cardiac magnetic resonance imaging (DS-CMRI) as a non-invasive technique to evaluate functional impairment due to significant TCAD.
54 patients at a mean interval of 7.2 years (range 0.9 to 16.8 ys) after HTX underwent rest and DS-CMRI. According to coronary angiography results patients were divided into 3 groups (1 = normal coronary arteries (CA), n = 29; 2 = CA stenosis < 75%, n = 15; 3 = significant CA stenosis > 75%, n = 10).
Patients with severe TCAD revealed impaired LV function at rest and during dobutamine stress compared to patients without or with only mild coronary artery stenosis. Additionally, a reduced functional reserve was non-invasively detected by DS-CMRI in patients with significant TCAD.
This article is published under license to BioMed Central Ltd.