- Meeting abstract
- Open Access
1014 Spiral imaging at 3 T for the measurement of endothelial-dependent coronary arterial function
© Hirsch et al; licensee BioMed Central Ltd. 2008
- Published: 22 October 2008
- Analyzable Frame
- Handgrip Exercise
- Isometric Handgrip
- Spiral Imaging
- Spiral Sequence
Invasive measures of endothelial-dependent coronary artery vasoreactivity predict cardiovascular event rates [1, 2]. We previously demonstrated that endothelial-dependent coronary vasoreactivity (EDCV) can be measured non-invasively by combining 3 T coronary MRI and isometric handgrip exercise . Although coronary vasoreactivity is likely a stronger a predictor of cardiac events than similar measures in peripheral arteries such as the brachial, there are several coronary MRI techniques in use but no currently standardized protocol for non-invasively assessing EDCV. We assessed EDCV with 3 T MRI at regular time intervals before, during and after isometric handgrip exercise using two different cine pulse sequences, gradient echo (TFE) and spiral.
Non-invasive measurement of coronary endothelial-dependent vasoreactivity is possible by combining isometric handgrip, 3 T coronary MRI and either TFE or spiral pulse sequences. Although fat-saturated spiral results in larger observed cross-sectional areas possibly due to off-resonance effects at 3 T, both sequences are adequate for these sequential measurements. The spiral method has a higher temporal resolution (23 ms vs. 47 ms) while maintaining both spatial resolution and breath-hold duration. This leads to a modest increase in the number of analyzable frames. Both methods clearly show a similar percentile stress-induced cross-sectional area change compared to baseline. Because SENSE is not necessary with spiral, quantitative SNR and CNR measurements may be more easily obtained. Isometric handgrip leads to early endothelial-dependent dilation at 30–60 seconds that is sustained throughout the handgrip exercise and quickly returns to baseline. For future studies we suggest the use of spiral imaging at baseline, during the first 4 min of handgrip exercise and after 4–5 minutes of recovery.
- Schachinger V, Britten MB, Zeiher AM: Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. Circulation. 2000, 101: 1899-1906.View ArticlePubMedGoogle Scholar
- Halcox JP, Schenke WH, Zalos G, Mincemoyer R, Prasad A, Waclawiw MA, Nour KR, Quyyumi AA: Prognostic value of coronary vascular endothelial dysfunction. Circulation. 2002, 106: 653-658. 10.1161/01.CIR.0000025404.78001.D8.View ArticlePubMedGoogle Scholar
- Hirsch GA, Weiss RG, Schar M, Gerstenblith G, Stuber M: Non-invasive measurement of coronary vasoreactivity using 3 T MRI. 10th Annual Scientific Sessions of the Society for Cardiovascular Magnetic Resonance, Rome, Italy. JCMR. 2007, 9: 93-168. p427 (Abstract 597)Google Scholar
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