- Meeting abstract
- Open Access
1028 The hyperenhanced region assessed by ex vivo DE-MRI is consistently larger than infarct size determined by TTC staining in the acute phase of reperfused ischemic myocardial injury
© Otto-student et al; licensee BioMed Central Ltd. 2008
- Published: 22 October 2008
- Infarct Size
- Left Anterior Descendant
- Left Ventricular Mass
- Myocardial Infarct Size
- Manual Delineation
The accuracy of DE-MRI measurement of myocardial infarct size in the acute phase has previously been investigated in different animal models. However, there is still an ongoing debate whether edematous reversible myocardial injury in the peri-infarction zone hyperenhances or not. If present, hyperenhancement of reversibly damaged myocardium will either lead to overestimation of the infarct size or indicate salvageable myocardium. The ability of DE-MRI to quantify myocardial infarct size has often been based on a slice to slice comparison between DE-MRI and corresponding TTC.
We wanted to evaluate the ability of ex vivo DE-MRI to depict and quantify acute myocardial necrosis on a global level using TTC as reference method in a closed chest pig model.
The global amount of hyperenhancement assessed by ex vivo DE-MRI is 27% larger than infarct size determined by TTC histochemistry in the acute phase. This may be attributed to hyperenhancement of both necrotic myocardium in the core of injury and injured but viable edematous myocardium in the peri-infarction zone. Thus, using hyperenhancement in DE-MRI as a definition of myocardial infarction will result in overestimation of myocardial infarct size in the acute phase of reperfused ischemic injury.
This article is published under license to BioMed Central Ltd.