1029 Agreement of left ventricular mass in steady state free precession (ssfp) and delayed enhancement (DE) MR images: implications for quantification of fibrosis in congenital and ischemic heart disease
© Stephensen et al; licensee BioMed Central Ltd. 2008
Published: 22 October 2008
The aim of the present study was to assess the agreement of determination of left ventricular mass between cine images acquired with ssfp and delayed enhancement images, and to see if they may be used interchangeably.
Cine ssfp and delayed enhancement images were aquired in 31 patients; 10 with no signs of fibrosis, 10 with ischemic heart disease and subendocardial fibrosis typical of infarction and 11 children with congenital heart disease but without signs of fibrosis in the left ventricle. Endo- and epicardium of the left ventricle was outlined in the ssfp images as well as the delayed contrast enhancement images.
Myocardial mass measured with ssfp images (126 ± 43 g, range 53–220 g) was significantly higher compared to delayed enhancement images (117 ± 44 g, range 42–201 g, p < 0.0001). Balanced cine images yielded 7,7% higher values of LV mass. The difference in LVM between ssfp and DE images remained if the 10 patients with infarcts were excluded (111 ± 38 g vs 101 ± 41 g respectively, p < 0.0001). The difference in LVM for the two image sequences was 6,3%.
Left ventricular mass is larger when measured with ssfp cine sequences than with DE sequences. Thus, the proportion of fibrosis of the LVM will differ by 6–8% depending if ssfp images or DE images are used to determine LVM. Therefore, a consensus statement regarding what sequences to be used, when determining the percentage of infarcted myocardium, is needed.
This article is published under license to BioMed Central Ltd.