1041 Assessment of the three-dimensional course of chronic totally occluded coronary arteries
© Rasche et al; licensee BioMed Central Ltd. 2008
Published: 22 October 2008
Several studies have revealed that successful revascularization of chronic total occlusion of coronary arteries confers a significant 10-year survival advantage over patients with failed or those without revascularization. The success-rate in revascularization, however, is still limited by the often insufficient knowledge of the three-dimensional course of the occluded artery, which is required for precise steering of the guide wires through the occlusion. In contrast to XR-angiography, MRI is capable of providing data of the occluded vessel without the need of contrast agent.
In this study, the feasibility of extracting the three-dimensional course of a totally occluded right coronary artery (RCA) by MRI is investigated.
The XR angiograms show a complete occlusion of the RCA starting in the ostium of the RCA (a). Retrograde filling shows enhancement of the distal parts of the RCA from the crux cordis onwards (b). In the respective 3D-MRI (c-f), the RCA can be clearly delineated from the surrounding fat and the entire course of the occluded section of the RCA can be extracted in 3D (g-i). Compared to the non-occluded sections, the signal from the occluded portion of the vessel (arrows in (d)) appears hypointense, likely due to the less pronounced effect of the SSFP sequence in thrombotic/fibrotic tissue.
Three-dimensional assessment of the course of the totally occluded RCA appears feasible. Since the MRI signal does not entirely rely on in-flow effects like in Angiography, even the totally occluded sections of the coronary could be clearly depicted. Due to the dimensions of the RCA and its complete embedding by fat in the atrioventricular groove, the identification of the occluded segment of the RCA could be done in the rather low spatial resolution images, which provided sufficient anatomical detail for identification of the vessel centerline. Next step will be the fusion of the centrerline information with XR-fluoroscopy during the intervention to provide advanced guidance during revascularization.
This article is published under license to BioMed Central Ltd.