- Meeting abstract
- Open Access
1069 Energy loss computation in the pulmonary arteries of repaired tetralogy of fallot subjects utilizing cardiac phase contrast MRI
© Gottliebson et al; licensee BioMed Central Ltd. 2008
- Published: 22 October 2008
- Pulmonary Artery
- Stroke Work
- Cardiac Phase
- Regurgitant Flow
- Contrast Flow
The cardiac MRI (CMR) pulmonary artery (PA) velocity-area relation (VAR) and pressure-flow relation (PFR) have been shown to change significantly in certain diseases of the PAs in which pulmonary valve function is normal. We hypothesized that the area within the PA VAR changed in concert with stroke work (an index of energy loss, represented by the integrated area of the PFR) in subjects with repaired Tetralogy of Fallot (rTOF) with residual pulmonary valve insufficiency (PI).
Concurrent catheterization (cath) and CMR data were analyzed for patients with rTOF and severe PI, and in control subjects without PI having normal as well as enlarged PAs due to a large left to right shunt. Cath data from the PAs was synchronized by ECG with concurrent MRI PA phase contrast flow (normalized to body surface area), PA cross-sectional area and PA pressure data. PA VAR and PFR curves were plotted for all subjects and the integrated areas within the curves were tabulated.
The CMR PA VAR curve characteristics mimic the changes in stroke work in subjects with rTOF and severe PI, and may be a reasonable non-invasive surrogate for assessment of PA thermodynamic and hemodynamic properties in this population.
This article is published under license to BioMed Central Ltd.