- Meeting abstract
- Open Access
119 Visualized microinfarction on contrast enhanced MR imaging linked to progressive left ventricular dysfunction
© Saeed et al; licensee BioMed Central Ltd. 2008
- Published: 22 October 2008
- Embolic Agent
- Remote Myocardium
- Systolic Wall
- Perfusion Territory
- Pass Perfusion
Clinical studies confirmed that microinfarction occurs in almost 1/4 of patients undergoing coronary intervention. There has been extensive debate about the etiology, mechanism and significance of microinfarction.
To directly and indirectly detect 1) discrete nonperfused myocardium induced by embolic agents using first passage perfusion, 2) hyperenhanced microinfarction on delayed contrast enhanced MRI (CE-MRI) and 3) changes in LV function.
Embolic agents between 100–500 μm were used to induce myocardial microinfarction in swine (n = 6). This was performed to simulate the clinical scenario, where different sizes of debris and thrombus scatter downstream from coronary plaques.
Discrete microinfarction, visualized on CE-MRI, can be directly linked to LV dysfunction. Additionally, it causes progressive decline in LV function. The observed changes are similar to that observed in ischemic cardiomyopathy.
This article is published under license to BioMed Central Ltd.