- Meeting abstract
- Open Access
1076 Effects of age and gender on right ventricular structure and function: a turning point at age fifty
© Goldman et al; licensee BioMed Central Ltd. 2008
- Published: 22 October 2008
- Ejection Fraction
- Cardiac Magnetic Resonance
- Right Ventricle
- Papillary Muscle
- Cardiac Magnetic Resonance Imaging
Cardiac magnetic resonance imaging (CMR) using steady-state free precession is the best method currently available for evaluating the right ventricle (RV).
Our objective was to assess effects of age and gender on RV structure and function in a large population of well characterized normal subjects using CMR.
We studied 218 (99 male, 119 female) normotensive, non-obese (BMI < 28), non-diabetic volunteers aged 20–90 (mean 54 ± 15) with normal 2-D echocardiograms on a 1.5 T Siemens Sonata scanner. TrueFISP cine imaging was used to obtain contiguous 8 mm short axis slices of the entire RV at end-expiration. Volumetric analysis was performed using Medis MASS. RV volume at end-diastole and end-systole and RV mass were determined and indexed to body surface area (EDVi, ESVi, RVMi) including papillary muscles in the cavity volume.
The right ventricle is larger, indexed for body size, in men than in women at all ages, while ejection fraction is higher in women. RV size falls with age, showing an abrupt decrement at age 50 in both men and women. The mechanisms underlying this dramatic change remain to be determined.
This article is published under license to BioMed Central Ltd.