- Meeting abstract
- Open Access
1103 Cardiovascular magnetic resonance assessment of epicardial fat volume: impact of weight reduction in obese males
© Nelson et al; licensee BioMed Central Ltd. 2008
- Published: 22 October 2008
- Waist Circumference
- Cardiovascular Magnetic Resonance
- Cardiac Magnetic Resonance
- Caloric Restriction
- Cardiac Magnetic Resonance Imaging
Epicardial fat covers 80% of the heart and constitutes 20% of its weight. Epicardial fat and its known relationship with abdominal obesity and coronary atherosclerosis, may render this a sensitive risk predictor of adverse cardiovascular events. The aim of this study was to effectively evaluate the impact of caloric restriction and associated weight reduction on epicardial fat volume via cardiac magnetic resonance imaging (CMR).
Thirty obese male subjects (BMI > 30 kg/m2) were evaluated as a subgroup of a larger study to assess effects of weight loss on myocardial and vascular structure and function. Weight loss was induced using a low calorie diet (~800 Kcal/day) for an 8 week period. At baseline and 8 weeks, CMR short axis images (1.5 T Siemens Sonata) were taken at 10 mm intervals through the ventricles. Consecutive end-diastolic images were analysed from the mitral valve plane through to the apex and using Image Pro Plus (MediaCybernetics, Maryland) regions of epicardial fat were traced and their area calculated. A modified Simpson's rule was then used to calculate epicardial fat volume with measurements made by a blinded technician. Intra-observer variability was <5%.
Epicardial fat is associated with both weight and waist circumference in the obese male. This is the first study to show a reduction in epicardial fat volume is associated with caloric restriction with further studies required to establish whether this is ultimately associated with improved myocardial function.
This article is published under license to BioMed Central Ltd.